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A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.
J Biol Chem. 2021 Jan-Jun;296:100634. doi: 10.1016/j.jbc.2021.100634. Epub 2021 Apr 3.
J Biol Chem. 2021.
PMID: 33823155
Free PMC article.
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME.
Tolosa EJ, et al. Among authors: horn ip.
Biochem J. 2020 Sep 18;477(17):3131-3145. doi: 10.1042/BCJ20200335.
Biochem J. 2020.
PMID: 32766732
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Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers.
Hogenson TL, Xie H, Phillips WJ, Toruner MD, Li JJ, Horn IP, Kennedy DJ, Almada LL, Marks DL, Carr RM, Toruner M, Sigafoos AN, Koenig-Kappes AN, Olson RL, Tolosa EJ, Zhang C, Li H, Doles JD, Bleeker J, Barrett MT, Boyum JH, Kipp BR, Mahipal A, Hubbard JM, Scheffler Hanson TJ, Petersen GM, Dasari S, Oberg AL, Truty MJ, Graham RP, Levy MJ, Zhu M, Billadeau DD, Adjei AA, Dusetti N, Iovanna JL, Bekaii-Saab TS, Ma WW, Fernandez-Zapico ME.
Hogenson TL, et al. Among authors: horn ip.
JCI Insight. 2022 Nov 22;7(22):e158060. doi: 10.1172/jci.insight.158060.
JCI Insight. 2022.
PMID: 36256477
Free PMC article.
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RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Carr RM, Vorobyev D, Lasho T, Marks DL, Tolosa EJ, Vedder A, Almada LL, Yurcheko A, Padioleau I, Alver B, Coltro G, Binder M, Safgren SL, Horn I, You X, Solary E, Balasis ME, Berger K, Hiebert J, Witzig T, Buradkar A, Graf T, Valent P, Mangaonkar AA, Robertson KD, Howard MT, Kaufmann SH, Pin C, Fernandez-Zapico ME, Geissler K, Droin N, Padron E, Zhang J, Nikolaev S, Patnaik MM.
Carr RM, et al.
Nat Commun. 2021 May 18;12(1):2901. doi: 10.1038/s41467-021-23186-w.
Nat Commun. 2021.
PMID: 34006870
Free PMC article.
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pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions.
Boyer MJ, Horn I, Firestone RA, Steele-Norwood D, Tannock IF.
Boyer MJ, et al.
Br J Cancer. 1993 Jan;67(1):81-7. doi: 10.1038/bjc.1993.13.
Br J Cancer. 1993.
PMID: 8427783
Free PMC article.
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