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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Kandasamy R, et al. Among authors: livingston ke. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2000017118. doi: 10.1073/pnas.2000017118. Proc Natl Acad Sci U S A. 2021. PMID: 33846240 Free PMC article.
Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor.
Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Bisignano P, et al. Among authors: livingston ke. J Chem Inf Model. 2015 Sep 28;55(9):1836-43. doi: 10.1021/acs.jcim.5b00388. Epub 2015 Sep 15. J Chem Inf Model. 2015. PMID: 26347990 Free PMC article.
Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A. Burford NT, et al. Among authors: livingston ke. J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007. Epub 2015 May 7. J Med Chem. 2015. PMID: 25901762 Free PMC article.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: livingston ke. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
68 results