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FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted.
Vallejo A, Erice O, Entrialgo-Cadierno R, Feliu I, Guruceaga E, Perugorria MJ, Olaizola P, Muggli A, Macaya I, O'Dell M, Ruiz-Fernandez de Cordoba B, Ortiz-Espinosa S, Hezel AF, Arozarena I, Lecanda F, Avila MA, Fernandez-Barrena MG, Evert M, Ponz-Sarvise M, Calvisi DF, Banales JM, Vicent S. Vallejo A, et al. J Hepatol. 2021 Aug;75(2):363-376. doi: 10.1016/j.jhep.2021.03.028. Epub 2021 Apr 20. J Hepatol. 2021. PMID: 33887357 Free article.
Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.
O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. O'Dell MR, et al. Cancer Res. 2012 Mar 15;72(6):1557-67. doi: 10.1158/0008-5472.CAN-11-3596. Epub 2012 Jan 20. Cancer Res. 2012. PMID: 22266220 Free PMC article.
ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.
Wang W, Friedland SC, Guo B, O'Dell MR, Alexander WB, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Myers JR, Ashton JM, Dunne RF, Steiner LA, Hezel AF. Wang W, et al. Gut. 2019 Jul;68(7):1245-1258. doi: 10.1136/gutjnl-2017-315541. Epub 2018 Sep 18. Gut. 2019. PMID: 30228219 Free PMC article.
GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity.
Ruffolo LI, Jackson KM, Kuhlers PC, Dale BS, Figueroa Guilliani NM, Ullman NA, Burchard PR, Qin SS, Juviler PG, Keilson JM, Morrison AB, Georger M, Jewell R, Calvi LM, Nywening TM, O'Dell MR, Hezel AF, De Las Casas L, Lesinski GB, Yeh JJ, Hernandez-Alejandro R, Belt BA, Linehan DC. Ruffolo LI, et al. Gut. 2022 Jul;71(7):1386-1398. doi: 10.1136/gutjnl-2021-324109. Epub 2021 Aug 19. Gut. 2022. PMID: 34413131 Free PMC article.
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.
Guo B, Friedland SC, Alexander W, Myers JA, Wang W, O'Dell MR, Getman M, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Mello SS, Vertino PM, Land HK, Steiner LA, Hezel AF. Guo B, et al. Among authors: o dell mr. Cell Rep. 2022 Aug 30;40(9):111253. doi: 10.1016/j.celrep.2022.111253. Cell Rep. 2022. PMID: 36044839 Free PMC article.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis.
Alexander WB, Wang W, Hill MA, O'Dell MR, Ruffolo LI, Guo B, Jackson KM, Ullman N, Friedland SC, McCall MN, Patel A, Figueroa-Guilliani N, Georger M, Belt BA, Whitney-Miller CL, Linehan DC, Murphy PJ, Hezel AF. Alexander WB, et al. Among authors: o dell mr. Dis Model Mech. 2024 Jun 1;17(6):dmm050358. doi: 10.1242/dmm.050358. Epub 2024 Feb 28. Dis Model Mech. 2024. PMID: 38415925 Free PMC article.
Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.
Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC. Satoh K, et al. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1116-23. doi: 10.1161/ATVBAHA.110.214601. Epub 2011 Feb 17. Arterioscler Thromb Vasc Biol. 2011. PMID: 21330604 Free PMC article.
227 results