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ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22phox activation in Aβ-induced retinal pigment epithelial cell injury.
Sun J, Chen J, Li T, Huang P, Li J, Shen M, Gao M, Sun Y, Liang J, Li X, Wang Y, Xiao Y, Shi X, Hu Y, Feng J, Jia H, Liu T, Sun X. Sun J, et al. Among authors: huang p. Theranostics. 2020 Sep 19;10(25):11637-11655. doi: 10.7150/thno.48064. eCollection 2020. Theranostics. 2020. PMID: 33052238 Free PMC article.
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. Fukuda S, et al. Among authors: huang p, huang x. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2022751118. doi: 10.1073/pnas.2022751118. Proc Natl Acad Sci U S A. 2021. PMID: 33526699 Free PMC article.
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
Ambati M, Apicella I, Wang SB, Narendran S, Leung H, Pereira F, Nagasaka Y, Huang P, Varshney A, Baker KL, Marion KM, Shadmehr M, Stains CI, Werner BC, Sadda SR, Taylor EW, Sutton SS, Magagnoli J, Gelfand BD. Ambati M, et al. Among authors: huang p. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2102975118. doi: 10.1073/pnas.2102975118. Proc Natl Acad Sci U S A. 2021. PMID: 34620711 Free PMC article.
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J. Narendran S, et al. Among authors: huang p. Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z. Signal Transduct Target Ther. 2021. PMID: 33850097 Free PMC article.
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