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Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation.
FEBS Open Bio. 2021 Jun;11(6):1719-1730. doi: 10.1002/2211-5463.13174. Epub 2021 May 12.
FEBS Open Bio. 2021.
PMID: 33979025
Free PMC article.
3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3.
Wik JA, Lundbäck P, la Cour Poulsen L, Haraldsen G, Skålhegg BS, Hol J.
Wik JA, et al.
PLoS One. 2020 Mar 4;15(3):e0229395. doi: 10.1371/journal.pone.0229395. eCollection 2020.
PLoS One. 2020.
PMID: 32130250
Free PMC article.
Item in Clipboard
Cellular metabolism dictates T cell effector function in health and disease.
Kolan SS, Li G, Wik JA, Malachin G, Guo S, Kolan P, Skålhegg BS.
Kolan SS, et al. Among authors: wik ja.
Scand J Immunol. 2020 Nov;92(5):e12956. doi: 10.1111/sji.12956. Epub 2020 Sep 19.
Scand J Immunol. 2020.
PMID: 32767795
Free article.
Review.
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Identification and characterization of a novel glutaminase inhibitor.
Cederkvist H, Kolan SS, Wik JA, Sener Z, Skålhegg BS.
Cederkvist H, et al. Among authors: wik ja.
FEBS Open Bio. 2022 Jan;12(1):163-174. doi: 10.1002/2211-5463.13319. Epub 2021 Nov 8.
FEBS Open Bio. 2022.
PMID: 34698439
Free PMC article.
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T Cell Metabolism in Infection.
Wik JA, Skålhegg BS.
Wik JA, et al.
Front Immunol. 2022 Mar 14;13:840610. doi: 10.3389/fimmu.2022.840610. eCollection 2022.
Front Immunol. 2022.
PMID: 35359994
Free PMC article.
Review.
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Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia.
Wik JA, Chowdhury A, Kolan S, Bastani NE, Li G, Alam K, Grimolizzi F, Skålhegg BS.
Wik JA, et al.
Biochem J. 2022 Jun 17;479(11):1221-1235. doi: 10.1042/BCJ20220144.
Biochem J. 2022.
PMID: 35695514
Free PMC article.
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Antibody blockade of Jagged1 attenuates choroidal neovascularization.
Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E.
Gjølberg TT, et al. Among authors: wik ja.
Nat Commun. 2023 May 30;14(1):3109. doi: 10.1038/s41467-023-38563-w.
Nat Commun. 2023.
PMID: 37253747
Free PMC article.
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