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Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM. Bailus BJ, et al. Among authors: ellerby lm. Autophagy. 2021 Dec;17(12):4119-4140. doi: 10.1080/15548627.2021.1904489. Epub 2021 May 24. Autophagy. 2021. PMID: 34024231 Free PMC article.
Autophagy: polyQ toxic fragment turnover.
Duncan C, Papanikolaou T, Ellerby LM. Duncan C, et al. Among authors: ellerby lm. Autophagy. 2010 Feb;6(2):312-4. doi: 10.4161/auto.6.2.11139. Epub 2010 Feb 6. Autophagy. 2010. PMID: 20104018 Free PMC article.
Mass spectrometric identification of novel lysine acetylation sites in huntingtin.
Cong X, Held JM, DeGiacomo F, Bonner A, Chen JM, Schilling B, Czerwieniec GA, Gibson BW, Ellerby LM. Cong X, et al. Among authors: ellerby lm. Mol Cell Proteomics. 2011 Oct;10(10):M111.009829. doi: 10.1074/mcp.M111.009829. Epub 2011 Jun 18. Mol Cell Proteomics. 2011. PMID: 21685499 Free PMC article.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. Gafni J, et al. Among authors: ellerby lm. J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012. J Neurosci. 2012. PMID: 22649225 Free PMC article.
112 results