ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.
Oshima S, Karrer EE, Paidhungat MM, Neighbors M, Chapin SJ, Fan RA, Reed MA, Wu K, Wong C, Chen Y, Whitlow M, Anderson FA, Bam RA, Zhang Q, Larsen BR, Viswanathan S, Devens BH, Bass SH, Higashi Y.
Oshima S, et al. Among authors: larsen br.
Protein Eng Des Sel. 2016 May;29(5):159-67. doi: 10.1093/protein/gzw002. Epub 2016 Mar 10.
Protein Eng Des Sel. 2016.
PMID: 26968452