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CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. Wang Q, et al. Among authors: murphy kr. Nat Commun. 2021 May 26;12(1):3175. doi: 10.1038/s41467-021-23549-3. Nat Commun. 2021. PMID: 34039988 Free PMC article.
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy.
Luczak ED, Wu Y, Granger JM, Joiner MA, Wilson NR, Gupta A, Umapathi P, Murphy KR, Reyes Gaido OE, Sabet A, Corradini E, Tseng WW, Wang Y, Heck AJR, Wei AC, Weiss RG, Anderson ME. Luczak ED, et al. Among authors: murphy kr. Nat Commun. 2020 Sep 4;11(1):4416. doi: 10.1038/s41467-020-18165-6. Nat Commun. 2020. PMID: 32887881 Free PMC article.
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. Konstantinidis K, et al. Among authors: murphy kr. J Clin Invest. 2020 Sep 1;130(9):4663-4678. doi: 10.1172/JCI133181. J Clin Invest. 2020. PMID: 32749237 Free PMC article.
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Mesubi OO, Rokita AG, Abrol N, Wu Y, Chen B, Wang Q, Granger JM, Tucker-Bartley A, Luczak ED, Murphy KR, Umapathi P, Banerjee PS, Boronina TN, Cole RN, Maier LS, Wehrens XH, Pomerantz JL, Song LS, Ahima RS, Hart GW, Zachara NE, Anderson ME. Mesubi OO, et al. Among authors: murphy kr. J Clin Invest. 2021 Jan 19;131(2):e95747. doi: 10.1172/JCI95747. J Clin Invest. 2021. PMID: 33151911 Free PMC article.
Impact of Clinical Characteristics and Biomarkers on AIRQ Exacerbation Prediction Ability.
Murphy KR, Beuther DA, Chipps B, Wise RA, McCann W, Reibman J, George M, Gilbert I, Eudicone JM, Gandhi HN, Ross M, Coyne KS, Zeiger RS. Murphy KR, et al. J Allergy Clin Immunol Pract. 2024 May 3:S2213-2198(24)00436-7. doi: 10.1016/j.jaip.2024.04.050. Online ahead of print. J Allergy Clin Immunol Pract. 2024. PMID: 38705273
Advancing assessment of asthma control with a composite tool: The Asthma Impairment and Risk Questionnaire.
Chipps BE, Zeiger RS, Beuther DA, Wise RA, McCann W, Reibman J, George M, Gilbert I, Eudicone JM, Coyne KS, Harding G, Murphy KR. Chipps BE, et al. Among authors: murphy kr. Ann Allergy Asthma Immunol. 2024 Mar 16:S1081-1206(24)00153-4. doi: 10.1016/j.anai.2024.03.011. Online ahead of print. Ann Allergy Asthma Immunol. 2024. PMID: 38494113 Free article.
Assessing meaningful change in the Asthma Impairment and Risk Questionnaire.
McCann W, Murphy KR, Zeiger RS, Beuther DA, Wise RA, Reibman J, George M, Gilbert I, Eudicone JM, Gandhi HN, Cutts K, Coyne KS, Chipps B. McCann W, et al. Among authors: murphy kr. Ann Allergy Asthma Immunol. 2024 Feb 17:S1081-1206(24)00085-1. doi: 10.1016/j.anai.2024.02.013. Online ahead of print. Ann Allergy Asthma Immunol. 2024. PMID: 38369256 Free article.
178 results