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Microbial exposure during early human development primes fetal immune cells.
Mishra A, Lai GC, Yao LJ, Aung TT, Shental N, Rotter-Maskowitz A, Shepherdson E, Singh GSN, Pai R, Shanti A, Wong RMM, Lee A, Khyriem C, Dutertre CA, Chakarov S, Srinivasan KG, Shadan NB, Zhang XM, Khalilnezhad S, Cottier F, Tan ASM, Low G, Chen P, Fan Y, Hor PX, Lee AKM, Choolani M, Vermijlen D, Sharma A, Fuks G, Straussman R, Pavelka N, Malleret B, McGovern N, Albani S, Chan JKY, Ginhoux F. Mishra A, et al. Among authors: chen p. Cell. 2021 Jun 24;184(13):3394-3409.e20. doi: 10.1016/j.cell.2021.04.039. Epub 2021 Jun 1. Cell. 2021. PMID: 34077752 Free PMC article.
Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal.
Leong JY, Chen P, Yeo JG, Ally F, Chua C, Nur Hazirah S, Poh SL, Pan L, Lai L, Lee ESC, Bathi LDT, Arkachaisri T, Lovell D, Albani S; Pediatric Rheumatology Collaborative Study Group. Leong JY, et al. Among authors: chen p. Ann Rheum Dis. 2019 Dec;78(12):1712-1721. doi: 10.1136/annrheumdis-2019-216059. Epub 2019 Sep 20. Ann Rheum Dis. 2019. PMID: 31540934 Free PMC article.
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