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A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
Nat Commun. 2021 Jun 7;12(1):3332. doi: 10.1038/s41467-021-23663-2.
Nat Commun. 2021.
PMID: 34099697
Free PMC article.
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL.
Rynearson KD, et al. Among authors: paquette wd.
Bioorg Med Chem Lett. 2016 Aug 15;26(16):3928-37. doi: 10.1016/j.bmcl.2016.07.011. Epub 2016 Jul 6.
Bioorg Med Chem Lett. 2016.
PMID: 27426299
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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL.
Rynearson KD, et al. Among authors: paquette wd.
Bioorg Med Chem. 2020 Nov 15;28(22):115734. doi: 10.1016/j.bmc.2020.115734. Epub 2020 Sep 1.
Bioorg Med Chem. 2020.
PMID: 33007551
Free PMC article.
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Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P.
George Rosenker KM, et al. Among authors: paquette wd.
Bioorg Med Chem. 2015 Jun 15;23(12):2810-8. doi: 10.1016/j.bmc.2015.01.043. Epub 2015 Jan 31.
Bioorg Med Chem. 2015.
PMID: 25703307
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Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.
Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, Johnston PA, Lazo JS, Wipf P.
Keinan S, et al. Among authors: paquette wd.
Org Biomol Chem. 2008 Sep 21;6(18):3256-63. doi: 10.1039/b806712k. Epub 2008 Jul 15.
Org Biomol Chem. 2008.
PMID: 18802630
Free PMC article.
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Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.
Johnston PA, Foster CA, Tierno MB, Shun TY, Shinde SN, Paquette WD, Brummond KM, Wipf P, Lazo JS.
Johnston PA, et al. Among authors: paquette wd.
Assay Drug Dev Technol. 2009 Jun;7(3):250-65. doi: 10.1089/adt.2008.186.
Assay Drug Dev Technol. 2009.
PMID: 19530895
Free PMC article.
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Enantioselective preparation of the C1-C11 fragment of apoptolidin.
Paquette WD, Taylor RE.
Paquette WD, et al.
Org Lett. 2004 Jan 8;6(1):103-6. doi: 10.1021/ol0361397.
Org Lett. 2004.
PMID: 14703361
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