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TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Di Tomasso G, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Vande Velde C. Sidibé H, et al. Among authors: khalfallah y. Brain. 2021 Dec 16;144(11):3461-3476. doi: 10.1093/brain/awab217. Brain. 2021. PMID: 34115105 Free PMC article.
TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
Deshaies JE, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett ER, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile S, Aulas A, Khalfallah Y, Soreq H, Nanci A, Strong MJ, Chabot B, Vande Velde C. Deshaies JE, et al. Among authors: khalfallah y. Brain. 2018 May 1;141(5):1320-1333. doi: 10.1093/brain/awy062. Brain. 2018. PMID: 29562314 Free PMC article.
TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.
Semmler S, Gagné M, Garg P, Pickles SR, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, Durcan TM, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM, Vande Velde C. Semmler S, et al. Among authors: khalfallah y. J Biol Chem. 2020 Mar 20;295(12):3808-3825. doi: 10.1074/jbc.RA119.011215. Epub 2020 Feb 6. J Biol Chem. 2020. PMID: 32029478 Free PMC article.
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Cochrane T, Chary S, Chew S, Zhu H, Wu F, Nestorov I, Graham D, Sun P, McNeill M, Fanning L, Ferguson TA, Fradette S; VALOR and OLE Working Group. Miller TM, et al. N Engl J Med. 2022 Sep 22;387(12):1099-1110. doi: 10.1056/NEJMoa2204705. N Engl J Med. 2022. PMID: 36129998 Free article. Clinical Trial.
HERV-K inactive or potential pathogens from within?
Khalfallah Y, Genge A. Khalfallah Y, et al. J Neurol Sci. 2021 Apr 15;423:117359. doi: 10.1016/j.jns.2021.117359. Epub 2021 Feb 20. J Neurol Sci. 2021. PMID: 33640108 No abstract available.
40 results