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Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Bame E, Tang H, Burns JC, Arefayene M, Michelsen K, Ma B, Marx I, Prince R, Roach AM, Poreci U, Donaldson D, Cullen P, Casey F, Zhu J, Carlile TM, Sangurdekar D, Zhang B, Trapa P, Santoro J, Muragan P, Pellerin A, Rubino S, Gianni D, Bajrami B, Peng X, Coppell A, Riester K, Belachew S, Mehta D, Palte M, Hopkins BT, Scaramozza M, Franchimont N, Mingueneau M. Bame E, et al. Among authors: rubino s. Clin Transl Immunology. 2021 Jun 14;10(6):e1295. doi: 10.1002/cti2.1295. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34141433 Free PMC article.
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response.
Pellerin K, Rubino SJ, Burns JC, Smith BA, McCarl CA, Zhu J, Jandreski L, Cullen P, Carlile TM, Li A, Rebollar JV, Sybulski J, Reynolds TL, Zhang B, Basile R, Tang H, Harp CP, Pellerin A, Silbereis J, Franchimont N, Cahir-McFarland E, Ransohoff RM, Cameron TO, Mingueneau M. Pellerin K, et al. Brain. 2021 Sep 4;144(8):2361-2374. doi: 10.1093/brain/awab231. Brain. 2021. PMID: 34145876
γδ T Cell-Secreted XCL1 Mediates Anti-CD3-Induced Oral Tolerance.
Rezende RM, Nakagaki BN, Moreira TG, Lopes JR, Kuhn C, Tatematsu BK, Boulenouar S, Maghzi AH, Rubino S, Menezes GB, Chitnis T, Weiner HL. Rezende RM, et al. Among authors: rubino s. J Immunol. 2019 Nov 15;203(10):2621-2629. doi: 10.4049/jimmunol.1900784. Epub 2019 Oct 2. J Immunol. 2019. PMID: 31578268 Free PMC article.
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Rubino SJ, et al. Nat Commun. 2018 Nov 1;9(1):4578. doi: 10.1038/s41467-018-05929-4. Nat Commun. 2018. PMID: 30385785 Free PMC article.
Identification and characterization of latency-associated peptide-expressing γδ T cells.
Rezende RM, da Cunha AP, Kuhn C, Rubino S, M'Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AMC, Weiner HL. Rezende RM, et al. Among authors: rubino s. Nat Commun. 2015 Dec 8;6:8726. doi: 10.1038/ncomms9726. Nat Commun. 2015. PMID: 26644347 Free PMC article.
Targeting latency-associated peptide promotes antitumor immunity.
Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Gabriely G, et al. Among authors: rubino s. Sci Immunol. 2017 May 19;2(11):eaaj1738. doi: 10.1126/sciimmunol.aaj1738. Sci Immunol. 2017. PMID: 28763794 Free PMC article.
324 results