Dorfmueller HC - Search Results

1

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A.

Arends DW, Miellet WR, Langereis JD, Ederveen THA, van der Gaast-de Jongh CE, van Scherpenzeel M, Knol MJ, van Sorge NM, Lefeber DJ, Trzciński K, Sanders EAM, Dorfmueller HC, Bootsma HJ, de Jonge MI. Arends DW, et al. Among authors: dorfmueller hc. Infect Immun. 2021 Oct 15;89(11):e0024621. doi: 10.1128/IAI.00246-21. Epub 2021 Jul 12. Infect Immun. 2021. PMID: 34251291 Free PMC article.

2

GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD).

van der Beek SL, Le Breton Y, Ferenbach AT, Chapman RN, van Aalten DM, Navratilova I, Boons GJ, McIver KS, van Sorge NM, Dorfmueller HC. van der Beek SL, et al. Among authors: dorfmueller hc. Mol Microbiol. 2015 Dec;98(5):946-62. doi: 10.1111/mmi.13169. Epub 2015 Oct 1. Mol Microbiol. 2015. PMID: 26278404 Free PMC article.

3

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification.

van der Beek SL, Zorzoli A, Çanak E, Chapman RN, Lucas K, Meyer BH, Evangelopoulos D, de Carvalho LPS, Boons GJ, Dorfmueller HC, van Sorge NM. van der Beek SL, et al. Among authors: dorfmueller hc. Mol Microbiol. 2019 Apr;111(4):951-964. doi: 10.1111/mmi.14197. Epub 2019 Jan 31. Mol Microbiol. 2019. PMID: 30600561 Free PMC article.

4

Modification of cell wall polysaccharide guides cell division in Streptococcus mutans.

Zamakhaeva S, Chaton CT, Rush JS, Ajay Castro S, Kenner CW, Yarawsky AE, Herr AB, van Sorge NM, Dorfmueller HC, Frolenkov GI, Korotkov KV, Korotkova N. Zamakhaeva S, et al. Among authors: dorfmueller hc. Nat Chem Biol. 2021 Aug;17(8):878-887. doi: 10.1038/s41589-021-00803-9. Epub 2021 May 27. Nat Chem Biol. 2021. PMID: 34045745 Free PMC article.

5

Group A, B, C, and G Streptococcus Lancefield antigen biosynthesis is initiated by a conserved α-d-GlcNAc-β-1,4-l-rhamnosyltransferase.

Zorzoli A, Meyer BH, Adair E, Torgov VI, Veselovsky VV, Danilov LL, Uhrin D, Dorfmueller HC. Zorzoli A, et al. Among authors: dorfmueller hc. J Biol Chem. 2019 Oct 18;294(42):15237-15256. doi: 10.1074/jbc.RA119.009894. Epub 2019 Sep 10. J Biol Chem. 2019. PMID: 31506299 Free PMC article.

6

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.

Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM. Rao FV, et al. Among authors: dorfmueller hc. EMBO J. 2006 Apr 5;25(7):1569-78. doi: 10.1038/sj.emboj.7601026. Epub 2006 Mar 16. EMBO J. 2006. PMID: 16541109 Free PMC article.

7

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.

Dorfmueller HC, Borodkin VS, Schimpl M, Shepherd SM, Shpiro NA, van Aalten DM. Dorfmueller HC, et al. J Am Chem Soc. 2006 Dec 27;128(51):16484-5. doi: 10.1021/ja066743n. J Am Chem Soc. 2006. PMID: 17177381 Free PMC article.

8

Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.

Pathak S, Dorfmueller HC, Borodkin VS, van Aalten DM. Pathak S, et al. Among authors: dorfmueller hc. Chem Biol. 2008 Aug 25;15(8):799-807. doi: 10.1016/j.chembiol.2008.06.010. Chem Biol. 2008. PMID: 18721751 Free PMC article.

9

Molecular mechanisms of O-GlcNAcylation.

Hurtado-Guerrero R, Dorfmueller HC, van Aalten DM. Hurtado-Guerrero R, et al. Among authors: dorfmueller hc. Curr Opin Struct Biol. 2008 Oct;18(5):551-7. doi: 10.1016/j.sbi.2008.09.005. Epub 2008 Oct 6. Curr Opin Struct Biol. 2008. PMID: 18822376 Review.

10

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation.

Dorfmueller HC, Borodkin VS, Schimpl M, van Aalten DM. Dorfmueller HC, et al. Biochem J. 2009 May 13;420(2):221-7. doi: 10.1042/BJ20090110. Biochem J. 2009. PMID: 19275764 Free PMC article.

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