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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.
Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, Üren A, Toretsky JA. Selvanathan SP, et al. Among authors: erkizan hv. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16. doi: 10.1073/pnas.1500536112. Epub 2015 Mar 3. Proc Natl Acad Sci U S A. 2015. PMID: 25737553 Free PMC article.
RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.
Erkizan HV, Schneider JA, Sajwan K, Graham GT, Griffin B, Chasovskikh S, Youbi SE, Kallarakal A, Chruszcz M, Padmanabhan R, Casey JL, Üren A, Toretsky JA. Erkizan HV, et al. Nucleic Acids Res. 2015 Jan;43(2):1069-80. doi: 10.1093/nar/gku1328. Epub 2015 Jan 6. Nucleic Acids Res. 2015. PMID: 25564528 Free PMC article.
Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.
Barber-Rotenberg JS, Selvanathan SP, Kong Y, Erkizan HV, Snyder TM, Hong SP, Kobs CL, South NL, Summer S, Monroe PJ, Chruszcz M, Dobrev V, Tosso PN, Scher LJ, Minor W, Brown ML, Metallo SJ, Üren A, Toretsky JA. Barber-Rotenberg JS, et al. Among authors: erkizan hv. Oncotarget. 2012 Feb;3(2):172-82. doi: 10.18632/oncotarget.454. Oncotarget. 2012. PMID: 22383402 Free PMC article.
Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.
Zöllner SK, Selvanathan SP, Graham GT, Commins RMT, Hong SH, Moseley E, Parks S, Haladyna JN, Erkizan HV, Dirksen U, Hogarty MD, Üren A, Toretsky JA. Zöllner SK, et al. Among authors: erkizan hv. Sci Signal. 2017 Oct 3;10(499):eaam8429. doi: 10.1126/scisignal.aam8429. Sci Signal. 2017. PMID: 28974650 Free PMC article.
19 results