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Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis.
Andres-Ejarque R, Ale HB, Grys K, Tosi I, Solanky S, Ainali C, Catak Z, Sreeneebus H, Saklatvala J, Dand N, de Rinaldis E, Chapman A, Nestle FO, Barnes MR, Warren RB, Reynolds NJ, Griffiths CEM, Barker JN, Smith CH, Di Meglio P; PSORT Consortium. Andres-Ejarque R, et al. Among authors: di meglio p. Nat Commun. 2021 Aug 6;12(1):4741. doi: 10.1038/s41467-021-25066-9. Nat Commun. 2021. PMID: 34362923 Free PMC article.
The association of age at psoriasis onset and HLA-C*06:02 with biologic survival in patients with moderate-to-severe psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).
Alabas OA, Mason KJ, Yiu ZZN, Warren RB, Dand N, Barker JN, Smith CH, Griffiths CEM; BADBIR and BSTOP study group. Alabas OA, et al. Br J Dermatol. 2024 Apr 17;190(5):689-700. doi: 10.1093/bjd/ljad481. Br J Dermatol. 2024. PMID: 38051972
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.
Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell P, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez-White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z; BSTOP study group; Estonian Biobank research team; Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT. Dand N, et al. Among authors: di meglio p. medRxiv [Preprint]. 2023 Oct 5:2023.10.04.23296543. doi: 10.1101/2023.10.04.23296543. medRxiv. 2023. PMID: 37873414 Free PMC article. Preprint.
Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2.
Lui PP, Ainali C, Chu CC, Terranova-Barberio M, Karagiannis P, Tewari A, Safinia N, Sharif-Paghaleh E, Tsoka S, Woszczek G, Di Meglio P, Lombardi G, Young AR, Nestle FO, Ali N. Lui PP, et al. Among authors: di meglio p. iScience. 2023 Sep 26;26(10):108029. doi: 10.1016/j.isci.2023.108029. eCollection 2023 Oct 20. iScience. 2023. PMID: 37860766 Free PMC article.
Nonadherence to systemic immune-modifying therapy in people with psoriasis during the COVID-19 pandemic: findings from a global cross-sectional survey.
Quirke-McFarlane S, Weinman J, Cook ES, Yiu ZZN, Dand N, Langan SM, Bechman K, Tsakok T, Mason KJ, McAteer H, Meynell F, Coker B, Vincent A, Urmston D, Vesty A, Kelly J, Lancelot C, Moorhead L, Barbosa IA, Bachelez H, Capon F, Contreras CR, De La Cruz C, Di Meglio P, Gisondi P, Jullien D, Lambert J, Naldi L, Puig L, Spuls P, Torres T, Warren RB, Waweru H, Galloway JB, Griffiths CEM, Barker JN, Norton S, Smith CH, Mahil SK; PsoProtect study group. Quirke-McFarlane S, et al. Among authors: di meglio p. Br J Dermatol. 2023 Apr 20;188(5):610-617. doi: 10.1093/bjd/ljac144. Br J Dermatol. 2023. PMID: 36763806
Biomarkers of systemic treatment response in people with psoriasis: a scoping review.
Corbett M, Ramessur R, Marshall D, Acencio ML, Ostaszewski M, Barbosa IA, Dand N, Di Meglio P, Haddad S, Jensen AHM, Koopmann W, Mahil SK, Rahmatulla S, Rastrick J, Saklatvala J, Weidinger S, Wright K, Eyerich K, Barker JN, Ndlovu M, Conrad C, Skov L, Smith CH; BIOMAP consortium. Corbett M, et al. Among authors: di meglio p. Br J Dermatol. 2022 Oct;187(4):494-506. doi: 10.1111/bjd.21677. Epub 2022 Jul 20. Br J Dermatol. 2022. PMID: 35606928 Free PMC article. Review.
Biomarkers of disease progression in people with psoriasis: a scoping review.
Ramessur R, Corbett M, Marshall D, Acencio ML, Barbosa IA, Dand N, Di Meglio P, Haddad S, Jensen AHM, Koopmann W, Mahil SK, Ostaszewski M, Rahmatulla S, Rastrick J, Saklatvala J, Weidinger S, Wright K, Eyerich K, Ndlovu M, Barker JN, Skov L, Conrad C, Smith CH; BIOMAP consortium. Ramessur R, et al. Among authors: di meglio p. Br J Dermatol. 2022 Oct;187(4):481-493. doi: 10.1111/bjd.21627. Epub 2022 Jul 11. Br J Dermatol. 2022. PMID: 35482474 Free PMC article. Review.
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR, Wielscher M, Yew YW, Baumbach C, Lee DP, Marouli E, Bernard M, Pfeiffer L, Matías-García PR, Autio MI, Bourgeois S, Herder C, Karhunen V, Meitinger T, Prokisch H, Rathmann W, Roden M, Sebert S, Shin J, Strauch K, Zhang W, Tan WLW, Hauck SM, Merl-Pham J, Grallert H, Barbosa EGV; MuTHER Consortium; Illig T, Peters A, Paus T, Pausova Z, Deloukas P, Foo RSY, Jarvelin MR, Kooner JS, Loh M, Heinig M, Gieger C, Waldenberger M, Chambers JC. Hawe JS, et al. Nat Genet. 2022 Jan;54(1):18-29. doi: 10.1038/s41588-021-00969-x. Epub 2022 Jan 3. Nat Genet. 2022. PMID: 34980917
Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study.
Mondelli V, Cattaneo A, Nikkheslat N, Souza L, Walsh A, Zajkowska Z, Zonca V, Marizzoni M, Fisher HL, Kohrt BA, Kieling C, Di Meglio P. Mondelli V, et al. Among authors: di meglio p. Brain Behav Immun Health. 2021 Nov 27;18:100396. doi: 10.1016/j.bbih.2021.100396. eCollection 2021 Dec. Brain Behav Immun Health. 2021. PMID: 34927102 Free PMC article.
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