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An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
Cancer Immunol Res. 2021 Oct;9(10):1141-1157. doi: 10.1158/2326-6066.CIR-21-0058. Epub 2021 Aug 10.
Cancer Immunol Res. 2021.
PMID: 34376502
CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus.
Andreata F, Moynihan KD, Fumagalli V, Di Lucia P, Pappas DC, Kawashima K, Ni I, Bessette PH, Perucchini C, Bono E, Giustini L, Nguyen HC, Chin SM, Yeung YA, Gibbs CS, Djuretic I, Iannacone M.
Andreata F, et al. Among authors: pappas dc.
Sci Transl Med. 2024 Jan 10;16(729):eadi1572. doi: 10.1126/scitranslmed.adi1572. Epub 2024 Jan 10.
Sci Transl Med. 2024.
PMID: 38198572
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IL-2 targeted to CD8+ T cells promotes robust effector T cell responses and potent antitumor immunity.
Moynihan KD, Kumar MP, Sultan H, Pappas DC, Park T, Chin SM, Bessette P, Lan RY, Nguyen HC, Mathewson ND, Ni I, Chen W, Lee Y, Liao-Chan S, Chen J, Schumacher TNM, Schreiber RD, Yeung YA, Djuretic IM.
Moynihan KD, et al. Among authors: pappas dc.
Cancer Discov. 2024 Apr 2. doi: 10.1158/2159-8290.CD-23-1266. Online ahead of print.
Cancer Discov. 2024.
PMID: 38563906
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Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease.
La Porte SL, Bollini SS, Lanz TA, Abdiche YN, Rusnak AS, Ho WH, Kobayashi D, Harrabi O, Pappas D, Mina EW, Milici AJ, Kawabe TT, Bales K, Lin JC, Pons J.
La Porte SL, et al.
J Mol Biol. 2012 Aug 24;421(4-5):525-36. doi: 10.1016/j.jmb.2011.11.047. Epub 2011 Dec 13.
J Mol Biol. 2012.
PMID: 22197375
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Evaluation and treatment of head and neck venous vascular malformations.
Pappas DC Jr, Persky MS, Berenstein A.
Pappas DC Jr, et al.
Ear Nose Throat J. 1998 Nov;77(11):914-6, 918-22.
Ear Nose Throat J. 1998.
PMID: 9846469
Clinical Trial.
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