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Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Zhang L, Lakkaniga NR, Bharate JB, Mcconnell N, Wang X, Kharbanda A, Leung YK, Frett B, Shah NP, Li HY. Zhang L, et al. Among authors: kharbanda a. Eur J Med Chem. 2021 Dec 5;225:113776. doi: 10.1016/j.ejmech.2021.113776. Epub 2021 Aug 17. Eur J Med Chem. 2021. PMID: 34479037 Free PMC article.
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
Zhang L, Moccia M, Briggs DC, Bharate JB, Lakkaniga NR, Knowles P, Yan W, Tran P, Kharbanda A, Wang X, Leung YK, Frett B, Santoro M, McDonald NQ, Carlomagno F, Li HY. Zhang L, et al. Among authors: kharbanda a. J Med Chem. 2022 Jan 27;65(2):1536-1551. doi: 10.1021/acs.jmedchem.1c01280. J Med Chem. 2022. PMID: 35081714 Free PMC article.
Tocotrienols as an Anti-Breast Cancer Agent.
Trujillo M, Kharbanda A, Corley C, Simmons P, Allen AR. Trujillo M, et al. Among authors: kharbanda a. Antioxidants (Basel). 2021 Aug 29;10(9):1383. doi: 10.3390/antiox10091383. Antioxidants (Basel). 2021. PMID: 34573015 Free PMC article. Review.
170 results