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Metabolic decisions in development and disease-a Keystone Symposia report.
Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. Cable J, et al. Among authors: perrimon n. Ann N Y Acad Sci. 2021 Dec;1506(1):55-73. doi: 10.1111/nyas.14678. Epub 2021 Aug 19. Ann N Y Acad Sci. 2021. PMID: 34414571 Review.
Downregulation of the tyrosine degradation pathway extends Drosophila lifespan.
Parkhitko AA, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen AL, Asara JM, Cracan V, Rabinowitz JD, Brockmann A, Perrimon N. Parkhitko AA, et al. Among authors: perrimon n. Elife. 2020 Dec 15;9:e58053. doi: 10.7554/eLife.58053. Elife. 2020. PMID: 33319750 Free PMC article.
mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. Cho S, et al. Among authors: perrimon n. Mol Cell. 2021 May 20;81(10):2064-2075.e8. doi: 10.1016/j.molcel.2021.03.010. Epub 2021 Mar 22. Mol Cell. 2021. PMID: 33756105 Free PMC article.
A genetic model of methionine restriction extends Drosophila health- and lifespan.
Parkhitko AA, Wang L, Filine E, Jouandin P, Leshchiner D, Binari R, Asara JM, Rabinowitz JD, Perrimon N. Parkhitko AA, et al. Among authors: perrimon n. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2110387118. doi: 10.1073/pnas.2110387118. Proc Natl Acad Sci U S A. 2021. PMID: 34588310 Free PMC article.
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.
Gu X, Jouandin P, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N, Sabatini DM. Gu X, et al. Among authors: perrimon n. Nature. 2022 Aug;608(7921):209-216. doi: 10.1038/s41586-022-04960-2. Epub 2022 Jul 20. Nature. 2022. PMID: 35859173 Free PMC article.
590 results