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Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
Yang T, Jackson VE, Smith AV, Chen H, Bartz TM, Sitlani CM, Psaty BM, Gharib SA, O'Connor GT, Dupuis J, Xu J, Lohman K, Liu Y, Kritchevsky SB, Cassano PA, Flexeder C, Gieger C, Karrasch S, Peters A, Schulz H, Harris SE, Starr JM, Deary IJ, Manichaikul A, Oelsner EC, Barr RG, Taylor KD, Rich SS, Bonten TN, Mook-Kanamori DO, Noordam R, Li-Gao R, Jarvelin MR, Wielscher M, Terzikhan N, Lahousse L, Brusselle G, Weiss S, Ewert R, Gläser S, Homuth G, Shrine N, Hall IP, Tobin M, London SJ, Wei P, Morrison AC. Yang T, et al. Among authors: chen h. Sci Rep. 2021 Sep 29;11(1):19365. doi: 10.1038/s41598-021-98120-7. Sci Rep. 2021. PMID: 34588469 Free PMC article.
Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.
Sarnowski C, Chen H, Biggs ML, Wassertheil-Smoller S, Bressler J, Irvin MR, Ryan KA, Karasik D, Arnett DK, Cupples LA, Fardo DW, Gogarten SM, Heavner BD, Jain D, Kang HM, Kooperberg C, Mainous AG, Mitchell BD, Morrison AC, O'Connell JR, Psaty BM, Rice K, Smith AV, Vasan RS, Windham BG, Kiel DP, Murabito JM, Lunetta KL; TOPMed Longevity and Healthy Aging Working Group; from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Sarnowski C, et al. Among authors: chen h. PLoS One. 2021 Jul 2;16(7):e0253611. doi: 10.1371/journal.pone.0253611. eCollection 2021. PLoS One. 2021. PMID: 34214102 Free PMC article.
Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies.
Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology and Hemostasis Working Group; Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X. Chen H, et al. Am J Hum Genet. 2019 Feb 7;104(2):260-274. doi: 10.1016/j.ajhg.2018.12.012. Epub 2019 Jan 10. Am J Hum Genet. 2019. PMID: 30639324 Free PMC article.
Genetic association testing using the GENESIS R/Bioconductor package.
Gogarten SM, Sofer T, Chen H, Yu C, Brody JA, Thornton TA, Rice KM, Conomos MP. Gogarten SM, et al. Among authors: chen h. Bioinformatics. 2019 Dec 15;35(24):5346-5348. doi: 10.1093/bioinformatics/btz567. Bioinformatics. 2019. PMID: 31329242 Free PMC article.
Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study.
Feofanova EV, Lim E, Chen H, Lee M, Liu CT, Cupples LA, Boerwinkle E. Feofanova EV, et al. Among authors: chen h. Genet Epidemiol. 2021 Sep;45(6):651-663. doi: 10.1002/gepi.22390. Epub 2021 Jun 24. Genet Epidemiol. 2021. PMID: 34167169 Free PMC article.
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