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Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H. Barker N, et al. Among authors: clevers h. Cell Rep. 2012 Sep 27;2(3):540-52. doi: 10.1016/j.celrep.2012.08.018. Epub 2012 Sep 20. Cell Rep. 2012. PMID: 22999937 Free article.
Bioengineered bile ducts recapitulate key cholangiocyte functions.
Chen C, Jochems PGM, Salz L, Schneeberger K, Penning LC, van de Graaf SFJ, Beuers U, Clevers H, Geijsen N, Masereeuw R, Spee B. Chen C, et al. Among authors: clevers h. Biofabrication. 2018 Jun 12;10(3):034103. doi: 10.1088/1758-5090/aac8fd. Biofabrication. 2018. PMID: 29848792
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H. Schutgens F, et al. Among authors: clevers h. Nat Biotechnol. 2019 Mar;37(3):303-313. doi: 10.1038/s41587-019-0048-8. Epub 2019 Mar 4. Nat Biotechnol. 2019. PMID: 30833775
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J. Calandrini C, et al. Among authors: clevers h. Nat Commun. 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. Nat Commun. 2020. PMID: 32161258 Free PMC article.
Kidney Organoids and Tubuloids.
Yousef Yengej FA, Jansen J, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Among authors: clevers h. Cells. 2020 May 26;9(6):1326. doi: 10.3390/cells9061326. Cells. 2020. PMID: 32466429 Free PMC article. Review.
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Gijzen L, Yousef Yengej FA, Schutgens F, Vormann MK, Ammerlaan CME, Nicolas A, Kurek D, Vulto P, Rookmaaker MB, Lanz HL, Verhaar MC, Clevers H. Gijzen L, et al. Among authors: clevers h. Nat Protoc. 2021 Apr;16(4):2023-2050. doi: 10.1038/s41596-020-00479-w. Epub 2021 Mar 5. Nat Protoc. 2021. PMID: 33674788
822 results