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Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D. McCarroll MN, et al. Among authors: kokel d. Nat Commun. 2019 Sep 9;10(1):4078. doi: 10.1038/s41467-019-11936-w. Nat Commun. 2019. PMID: 31501447 Free PMC article.
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Bruni G, et al. Among authors: kokel d. Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239787 Free PMC article.
A non-hallucinogenic psychedelic analogue with therapeutic potential.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. Cameron LP, et al. Among authors: kokel d. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299186 Free PMC article.
Chemical informatics and target identification in a zebrafish phenotypic screen.
Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL Jr, Roth BL, Peterson RT, Shoichet BK. Laggner C, et al. Among authors: kokel d. Nat Chem Biol. 2011 Dec 18;8(2):144-6. doi: 10.1038/nchembio.732. Nat Chem Biol. 2011. PMID: 22179068 Free PMC article.
σ1 receptor ligands control a switch between passive and active threat responses.
Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT. Rennekamp AJ, et al. Among authors: kokel d. Nat Chem Biol. 2016 Jul;12(7):552-8. doi: 10.1038/nchembio.2089. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239788 Free PMC article.
Identification of nonvisual photomotor response cells in the vertebrate hindbrain.
Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT. Kokel D, et al. J Neurosci. 2013 Feb 27;33(9):3834-43. doi: 10.1523/JNEUROSCI.3689-12.2013. J Neurosci. 2013. PMID: 23447595 Free PMC article.
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