Powell JD - Search Results

1

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ. Mo F, et al. Among authors: powell jd. Nature. 2021 Sep;597(7877):544-548. doi: 10.1038/s41586-021-03861-0. Epub 2021 Sep 15. Nature. 2021. PMID: 34526724 Free PMC article.

2

Quieting T cells with Slfn2.

Horton MR, Powell JD. Horton MR, et al. Among authors: powell jd. Nat Immunol. 2010 Apr;11(4):281-2. doi: 10.1038/ni0410-281. Nat Immunol. 2010. PMID: 20300134 Free PMC article. Review.

3

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.

Pollizzi KN, Powell JD. Pollizzi KN, et al. Among authors: powell jd. Nat Rev Immunol. 2014 Jul;14(7):435-46. doi: 10.1038/nri3701. Nat Rev Immunol. 2014. PMID: 24962260 Free PMC article. Review.

4

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD. Pollizzi KN, et al. Among authors: powell jd. Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. Epub 2016 Apr 11. Nat Immunol. 2016. PMID: 27064374 Free PMC article.

5

Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer.

Singh AK, Praharaj M, Lombardo KA, Yoshida T, Matoso A, Baras AS, Zhao L, Srikrishna G, Huang J, Prasad P, Powell JD, Kates M, McConkey D, Pardoll DM, Bishai WR, Bivalacqua TJ. Singh AK, et al. Among authors: powell jd. Nat Commun. 2022 Feb 15;13(1):878. doi: 10.1038/s41467-022-28509-z. Nat Commun. 2022. PMID: 35169141 Free PMC article.

6

Persistent CAD activity in memory CD8⁺ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge.

Claiborne MD, Sengupta S, Zhao L, Arwood ML, Sun IM, Wen J, Thompson EA, Mitchell-Flack M, Laiho M, Powell JD. Claiborne MD, et al. Among authors: powell jd. Sci Immunol. 2022 May 27;7(71):eabh4271. doi: 10.1126/sciimmunol.abh4271. Epub 2022 May 27. Sci Immunol. 2022. PMID: 35622902 Free PMC article.

7

GOT1 regulates CD8⁺ effector and memory T cell generation.

Xu W, Patel CH, Zhao L, Sun IH, Oh MH, Sun IM, Helms RS, Wen J, Powell JD. Xu W, et al. Among authors: powell jd. Cell Rep. 2023 Jan 31;42(1):111987. doi: 10.1016/j.celrep.2022.111987. Epub 2023 Jan 12. Cell Rep. 2023. PMID: 36640309 Free PMC article.

8

GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation.

Xu W, Patel CH, Alt J, Zhao L, Sun IH, Oh MH, Sun IM, Wen J, Blosser RL, Tam AJ, Powell JD. Xu W, et al. Among authors: powell jd. Nature. 2023 Feb;614(7946):E1-E11. doi: 10.1038/s41586-022-05602-3. Epub 2023 Feb 1. Nature. 2023. PMID: 36726001 No abstract available.

9

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.

Parveen S, Shen J, Lun S, Zhao L, Alt J, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, Bishai WR. Parveen S, et al. Among authors: powell jd. Nat Commun. 2023 Nov 16;14(1):7427. doi: 10.1038/s41467-023-43304-0. Nat Commun. 2023. PMID: 37973991 Free PMC article.

10

Egr-2 and Egr-3 are negative regulators of T cell activation.

Safford M, Collins S, Lutz MA, Allen A, Huang CT, Kowalski J, Blackford A, Horton MR, Drake C, Schwartz RH, Powell JD. Safford M, et al. Among authors: powell jd. Nat Immunol. 2005 May;6(5):472-80. doi: 10.1038/ni1193. Epub 2005 Apr 17. Nat Immunol. 2005. PMID: 15834410

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