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The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination.
Tomalka JA, Pelletier AN, Fourati S, Latif MB, Sharma A, Furr K, Carlson K, Lifton M, Gonzalez A, Wilkinson P, Franchini G, Parks R, Letvin N, Yates N, Seaton K, Tomaras G, Tartaglia J, Robb ML, Michael NL, Koup R, Haynes B, Santra S, Sekaly RP. Tomalka JA, et al. Among authors: sekaly rp. Nat Immunol. 2021 Oct;22(10):1294-1305. doi: 10.1038/s41590-021-01026-9. Epub 2021 Sep 23. Nat Immunol. 2021. PMID: 34556879 Free PMC article.
A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.
Ehrenberg PK, Shangguan S, Issac B, Alter G, Geretz A, Izumi T, Bryant C, Eller MA, Wegmann F, Apps R, Creegan M, Bolton DL, Sekaly RP, Robb ML, Gramzinski RA, Pau MG, Schuitemaker H, Barouch DH, Michael NL, Thomas R. Ehrenberg PK, et al. Among authors: sekaly rp. Sci Transl Med. 2019 Aug 28;11(507):eaaw4236. doi: 10.1126/scitranslmed.aaw4236. Sci Transl Med. 2019. PMID: 31462510 Free PMC article.
Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition.
Gorini G, Fourati S, Vaccari M, Rahman MA, Gordon SN, Brown DR, Law L, Chang J, Green R, Barrenäs F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale M Jr, Sekaly RP, Franchini G. Gorini G, et al. Among authors: sekaly rp. PLoS Pathog. 2020 Mar 12;16(3):e1008377. doi: 10.1371/journal.ppat.1008377. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32163525 Free PMC article.
The sooner the better: innate immunity as a path toward the HIV cure.
Tomalka J, Ghneim K, Bhattacharyya S, Aid M, Barouch DH, Sekaly RP, Ribeiro SP. Tomalka J, et al. Among authors: sekaly rp. Curr Opin Virol. 2016 Aug;19:85-91. doi: 10.1016/j.coviro.2016.07.003. Epub 2016 Aug 3. Curr Opin Virol. 2016. PMID: 27497036 Review.
A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. Pino M, et al. Among authors: sekaly rp. Sci Immunol. 2021 Jul 15;6(61):eabh3634. doi: 10.1126/sciimmunol.abh3634. Sci Immunol. 2021. PMID: 34266981 Free PMC article.
Translocated microbiome composition determines immunological outcome in treated HIV infection.
Nganou-Makamdop K, Talla A, Sharma AA, Darko S, Ransier A, Laboune F, Chipman JG, Beilman GJ, Hoskuldsson T, Fourati S, Schmidt TE, Arumugam S, Lima NS, Moon D, Callisto S, Schoephoerster J, Tomalka J, Mugyenyi P, Ssali F, Muloma P, Ssengendo P, Leda AR, Cheu RK, Flynn JK, Morou A, Brunet-Ratnasingham E, Rodriguez B, Lederman MM, Kaufmann DE, Klatt NR, Kityo C, Brenchley JM, Schacker TW, Sekaly RP, Douek DC. Nganou-Makamdop K, et al. Among authors: sekaly rp. Cell. 2021 Jul 22;184(15):3899-3914.e16. doi: 10.1016/j.cell.2021.05.023. Epub 2021 Jul 7. Cell. 2021. PMID: 34237254 Free PMC article.
Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody.
Asokan M, Dias J, Liu C, Maximova A, Ernste K, Pegu A, McKee K, Shi W, Chen X, Almasri C, Promsote W, Ambrozak DR, Gama L, Hu J, Douek DC, Todd JP, Lifson JD, Fourati S, Sekaly RP, Crowley AR, Ackerman ME, Ko SH, Kilam D, Boritz EA, Liao LE, Best K, Perelson AS, Mascola JR, Koup RA. Asokan M, et al. Among authors: sekaly rp. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18754-18763. doi: 10.1073/pnas.2008236117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690707 Free PMC article.
383 results