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IRF3-mediated pathogenicity in a murine model of human hepatitis A.
Sun L, Li Y, Misumi I, González-López O, Hensley L, Cullen JM, McGivern DR, Matsuda M, Suzuki R, Sen GC, Hirai-Yuki A, Whitmire JK, Lemon SM. Sun L, et al. Among authors: sen gc. PLoS Pathog. 2021 Sep 30;17(9):e1009960. doi: 10.1371/journal.ppat.1009960. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34591933 Free PMC article.
Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.
Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC. Fensterl V, et al. Among authors: sen gc. PLoS Pathog. 2012;8(5):e1002712. doi: 10.1371/journal.ppat.1002712. Epub 2012 May 17. PLoS Pathog. 2012. PMID: 22615570 Free PMC article.
IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation.
Popli S, Chakravarty S, Fan S, Glanz A, Aras S, Nagy LE, Sen GC, Chakravarti R, Chattopadhyay S. Popli S, et al. Among authors: sen gc. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2121385119. doi: 10.1073/pnas.2121385119. Epub 2022 Sep 6. Proc Natl Acad Sci U S A. 2022. PMID: 36067309 Free PMC article.
Viral apoptosis is induced by IRF-3-mediated activation of Bax.
Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC. Chattopadhyay S, et al. Among authors: sen gc. EMBO J. 2010 May 19;29(10):1762-73. doi: 10.1038/emboj.2010.50. Epub 2010 Apr 1. EMBO J. 2010. PMID: 20360684 Free PMC article.
248 results