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Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
Welz L, Kakavand N, Hang X, Laue G, Ito G, Silva MG, Plattner C, Mishra N, Tengen F, Ogris C, Jesinghaus M, Wottawa F, Arnold P, Kaikkonen L, Stengel S, Tran F, Das S, Kaser A, Trajanoski Z, Blumberg R, Roecken C, Saur D, Tschurtschenthaler M, Schreiber S, Rosenstiel P, Aden K. Welz L, et al. Among authors: tschurtschenthaler m. Gastroenterology. 2022 Jan;162(1):223-237.e11. doi: 10.1053/j.gastro.2021.09.057. Epub 2021 Sep 30. Gastroenterology. 2022. PMID: 34599932 Free PMC article.
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells.
Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A. Niederreiter L, et al. Among authors: tschurtschenthaler m. J Exp Med. 2013 Sep 23;210(10):2041-56. doi: 10.1084/jem.20122341. Epub 2013 Sep 16. J Exp Med. 2013. PMID: 24043762 Free PMC article.
Paneth cells as a site of origin for intestinal inflammation.
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Adolph TE, et al. Among authors: tschurtschenthaler m. Nature. 2013 Nov 14;503(7475):272-6. doi: 10.1038/nature12599. Epub 2013 Oct 2. Nature. 2013. PMID: 24089213 Free PMC article.
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.
Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. Afrazi A, et al. Among authors: tschurtschenthaler m. J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11. J Biol Chem. 2014. PMID: 24519940 Free PMC article.
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A. Tschurtschenthaler M, et al. J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12. J Exp Med. 2017. PMID: 28082357 Free PMC article.
Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation.
Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R. Hosomi S, et al. Among authors: tschurtschenthaler m. J Exp Med. 2017 Oct 2;214(10):2985-2997. doi: 10.1084/jem.20162041. Epub 2017 Jul 26. J Exp Med. 2017. PMID: 28747426 Free PMC article.
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P. Aden K, et al. Among authors: tschurtschenthaler m. J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25. J Exp Med. 2018. PMID: 30254094 Free PMC article.
IDO1+ Paneth cells promote immune escape of colorectal cancer.
Pflügler S, Svinka J, Scharf I, Crncec I, Filipits M, Charoentong P, Tschurtschenthaler M, Kenner L, Awad M, Stift J, Schernthanner M, Bischl R, Herndler-Brandstetter D, Glitzner E, Moll HP, Casanova E, Timelthaler G, Sibilia M, Gnant M, Lax S, Thaler J, Müller M, Strobl B, Mohr T, Kaser A, Trajanoski Z, Heller G, Eferl R. Pflügler S, et al. Among authors: tschurtschenthaler m. Commun Biol. 2020 May 22;3(1):252. doi: 10.1038/s42003-020-0989-y. Commun Biol. 2020. PMID: 32444775 Free PMC article.
28 results