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Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Min J, Mayasundari A, Keramatnia F, Jonchere B, Yang SW, Jarusiewicz J, Actis M, Das S, Young B, Slavish J, Yang L, Li Y, Fu X, Garrett SH, Yun MK, Li Z, Nithianantham S, Chai S, Chen T, Shelat A, Lee RE, Nishiguchi G, White SW, Roussel MF, Potts PR, Fischer M, Rankovic Z. Min J, et al. Among authors: chai s. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. doi: 10.1002/anie.202108848. Epub 2021 Nov 16. Angew Chem Int Ed Engl. 2021. PMID: 34614283 Free PMC article.
Role of CAR and PXR in xenobiotic sensing and metabolism.
Wang YM, Ong SS, Chai SC, Chen T. Wang YM, et al. Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):803-17. doi: 10.1517/17425255.2012.685237. Epub 2012 May 3. Expert Opin Drug Metab Toxicol. 2012. PMID: 22554043 Free PMC article. Review.
Pregnane X receptor and drug-induced liver injury.
Wang YM, Chai SC, Brewer CT, Chen T. Wang YM, et al. Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1521-32. doi: 10.1517/17425255.2014.963555. Epub 2014 Sep 25. Expert Opin Drug Metab Toxicol. 2014. PMID: 25252616 Free PMC article. Review.
Small-molecule modulators of the constitutive androstane receptor.
Cherian MT, Chai SC, Chen T. Cherian MT, et al. Expert Opin Drug Metab Toxicol. 2015 Jul;11(7):1099-114. doi: 10.1517/17425255.2015.1043887. Epub 2015 May 15. Expert Opin Drug Metab Toxicol. 2015. PMID: 25979168 Free PMC article. Review.
Small-molecule modulators of PXR and CAR.
Chai SC, Cherian MT, Wang YM, Chen T. Chai SC, et al. Biochim Biophys Acta. 2016 Sep;1859(9):1141-1154. doi: 10.1016/j.bbagrm.2016.02.013. Epub 2016 Feb 24. Biochim Biophys Acta. 2016. PMID: 26921498 Free PMC article. Review.
1,352 results