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Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.
Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP. Zunica ERM, et al. Among authors: hoppel cl. Cancer Metab. 2021 Oct 9;9(1):36. doi: 10.1186/s40170-021-00274-5. Cancer Metab. 2021. PMID: 34627389 Free PMC article.
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: hoppel cl. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10. EMBO Mol Med. 2020. PMID: 32519812 Free PMC article.
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: hoppel cl. Metabolism. 2021 Aug;121:154803. doi: 10.1016/j.metabol.2021.154803. Epub 2021 Jun 4. Metabolism. 2021. PMID: 34090870 Free PMC article. Clinical Trial.
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.
King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP. King WT, et al. Among authors: hoppel cl. J Biol Chem. 2021 Oct;297(4):101196. doi: 10.1016/j.jbc.2021.101196. Epub 2021 Sep 13. J Biol Chem. 2021. PMID: 34529976 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35559494
Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.
Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S. Kumar A, et al. Among authors: hoppel cl. Free Radic Biol Med. 2019 Dec;145:284-299. doi: 10.1016/j.freeradbiomed.2019.09.031. Epub 2019 Sep 28. Free Radic Biol Med. 2019. PMID: 31574345 Free PMC article.
355 results