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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Jarvis LB, Rainbow DB, Coppard V, Howlett SK, Georgieva Z, Davies JL, Mullay HK, Hester J, Ashmore T, Van Den Bosch A, Grist JT, Coles AJ, Mousa HS, Pluchino S, Mahbubani KT, Griffin JL, Saeb-Parsy K, Issa F, Peruzzotti-Jametti L, Wicker LS, Jones JL. Jarvis LB, et al. Among authors: mahbubani kt. Commun Biol. 2021 Oct 14;4(1):1186. doi: 10.1038/s42003-021-02721-x. Commun Biol. 2021. PMID: 34650224 Free PMC article.
Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy-induced cytokine release syndrome.
Matas-Céspedes A, Brown L, Mahbubani KT, Bareham B, Higgins J, Curran M, de Haan L, Lapointe JM, Stebbings R, Saeb-Parsy K. Matas-Céspedes A, et al. Among authors: mahbubani kt. Clin Transl Immunology. 2020 Nov 4;9(11):e1202. doi: 10.1002/cti2.1202. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33173582 Free PMC article.
Cross-tissue immune cell analysis reveals tissue-specific features in humans.
Domínguez Conde C, Xu C, Jarvis LB, Rainbow DB, Wells SB, Gomes T, Howlett SK, Suchanek O, Polanski K, King HW, Mamanova L, Huang N, Szabo PA, Richardson L, Bolt L, Fasouli ES, Mahbubani KT, Prete M, Tuck L, Richoz N, Tuong ZK, Campos L, Mousa HS, Needham EJ, Pritchard S, Li T, Elmentaite R, Park J, Rahmani E, Chen D, Menon DK, Bayraktar OA, James LK, Meyer KB, Yosef N, Clatworthy MR, Sims PA, Farber DL, Saeb-Parsy K, Jones JL, Teichmann SA. Domínguez Conde C, et al. Among authors: mahbubani kt. Science. 2022 May 13;376(6594):eabl5197. doi: 10.1126/science.abl5197. Epub 2022 May 13. Science. 2022. PMID: 35549406 Free PMC article.
Somatic mutant clones colonize the human esophagus with age.
Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH. Martincorena I, et al. Science. 2018 Nov 23;362(6417):911-917. doi: 10.1126/science.aau3879. Epub 2018 Oct 18. Science. 2018. PMID: 30337457 Free PMC article.
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation.
Madissoon E, Wilbrey-Clark A, Miragaia RJ, Saeb-Parsy K, Mahbubani KT, Georgakopoulos N, Harding P, Polanski K, Huang N, Nowicki-Osuch K, Fitzgerald RC, Loudon KW, Ferdinand JR, Clatworthy MR, Tsingene A, van Dongen S, Dabrowska M, Patel M, Stubbington MJT, Teichmann SA, Stegle O, Meyer KB. Madissoon E, et al. Among authors: mahbubani kt. Genome Biol. 2019 Dec 31;21(1):1. doi: 10.1186/s13059-019-1906-x. Genome Biol. 2019. PMID: 31892341 Free PMC article.
The mutational landscape of normal human endometrial epithelium.
Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P, Dentro SC, Dawson KJ, Butler T, Rahbari R, Mitchell TJ, Maura F, Nangalia J, Tarpey PS, Brunner SF, Lee-Six H, Hooks Y, Moody S, Mahbubani KT, Jimenez-Linan M, Brosens JJ, Iacobuzio-Donahue CA, Martincorena I, Saeb-Parsy K, Campbell PJ, Stratton MR. Moore L, et al. Among authors: mahbubani kt. Nature. 2020 Apr;580(7805):640-646. doi: 10.1038/s41586-020-2214-z. Epub 2020 Apr 22. Nature. 2020. PMID: 32350471
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Martin JL, et al. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y. Nat Metab. 2019. PMID: 32395697 Free PMC article.
39 results