Günther M - Search Results

1

Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.

Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. Wittlinger F, et al. Among authors: gunther m. J Med Chem. 2022 Jan 27;65(2):1370-1383. doi: 10.1021/acs.jmedchem.1c00848. Epub 2021 Oct 20. J Med Chem. 2022. PMID: 34668706 Free PMC article.

2

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.

Juchum M, Günther M, Döring E, Sievers-Engler A, Lämmerhofer M, Laufer S. Juchum M, et al. Among authors: gunther m. J Med Chem. 2017 Jun 8;60(11):4636-4656. doi: 10.1021/acs.jmedchem.7b00178. Epub 2017 May 23. J Med Chem. 2017. PMID: 28482151

3

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.

Heppner DE, Günther M, Wittlinger F, Laufer SA, Eck MJ. Heppner DE, et al. Among authors: gunther m. J Med Chem. 2020 Apr 23;63(8):4293-4305. doi: 10.1021/acs.jmedchem.0c00200. Epub 2020 Apr 14. J Med Chem. 2020. PMID: 32243152 Free PMC article.

4

Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.

Muth F, Günther M, Bauer SM, Döring E, Fischer S, Maier J, Drückes P, Köppler J, Trappe J, Rothbauer U, Koch P, Laufer SA. Muth F, et al. Among authors: gunther m. J Med Chem. 2015 Jan 8;58(1):443-56. doi: 10.1021/jm501557a. Epub 2014 Dec 5. J Med Chem. 2015. PMID: 25475894

5

Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors.

Juchum M, Günther M, Laufer SA. Juchum M, et al. Among authors: gunther m. Drug Resist Updat. 2015 May;20:12-28. doi: 10.1016/j.drup.2015.05.002. Epub 2015 May 12. Drug Resist Updat. 2015. PMID: 26021435 Review.

6

Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy-Resistant L858R/T790M/C797S Mutant.

Günther M, Juchum M, Kelter G, Fiebig H, Laufer S. Günther M, et al. Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10890-4. doi: 10.1002/anie.201603736. Epub 2016 Jul 28. Angew Chem Int Ed Engl. 2016. PMID: 27466205

7

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.

Günther M, Lategahn J, Juchum M, Döring E, Keul M, Engel J, Tumbrink HL, Rauh D, Laufer S. Günther M, et al. J Med Chem. 2017 Jul 13;60(13):5613-5637. doi: 10.1021/acs.jmedchem.7b00316. Epub 2017 Jun 21. J Med Chem. 2017. PMID: 28603991

8

Synthesis and structure‑activity‑relationship of 3,4‑Diaryl‑1H‑pyrrolo[2,3‑b]pyridines as irreversible Inhibitors of mutant EGFR‑L858R/T790M.

Günther M, Laux J, Laufer S. Günther M, et al. Eur J Pharm Sci. 2019 Feb 1;128:91-96. doi: 10.1016/j.ejps.2018.11.021. Epub 2018 Nov 22. Eur J Pharm Sci. 2019. PMID: 30471411

9

Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation.

Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta V, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Bayrak A, et al. Among authors: gunther m. J Med Chem. 2022 Oct 13;65(19):13365-13384. doi: 10.1021/acs.jmedchem.2c01198. Epub 2022 Sep 23. J Med Chem. 2022. PMID: 36150079

10

High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens.

Günther M, Laufer S, Schmidt PC. Günther M, et al. Phytochem Anal. 2006 Jan-Feb;17(1):1-7. doi: 10.1002/pca.822. Phytochem Anal. 2006. PMID: 16454469

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