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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. Zhang D, et al. Among authors: guan kl. J Clin Invest. 2010 Aug;120(8):2805-16. doi: 10.1172/JCI43008. Epub 2010 Jul 19. J Clin Invest. 2010. PMID: 20644257 Free PMC article.
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. Yu FX, et al. Among authors: guan kl. Cancer Cell. 2014 Jun 16;25(6):822-30. doi: 10.1016/j.ccr.2014.04.017. Epub 2014 May 29. Cancer Cell. 2014. PMID: 24882516 Free PMC article.
Hippo pathway regulation of gastrointestinal tissues.
Yu FX, Meng Z, Plouffe SW, Guan KL. Yu FX, et al. Among authors: guan kl. Annu Rev Physiol. 2015;77:201-27. doi: 10.1146/annurev-physiol-021014-071733. Epub 2014 Sep 29. Annu Rev Physiol. 2015. PMID: 25293527 Review.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. Jewell JL, et al. Among authors: guan kl. Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7. Science. 2015. PMID: 25567907 Free PMC article.
The emerging roles of YAP and TAZ in cancer.
Moroishi T, Hansen CG, Guan KL. Moroishi T, et al. Among authors: guan kl. Nat Rev Cancer. 2015 Feb;15(2):73-79. doi: 10.1038/nrc3876. Epub 2015 Jan 16. Nat Rev Cancer. 2015. PMID: 25592648 Free PMC article. Review.
Disease implications of the Hippo/YAP pathway.
Plouffe SW, Hong AW, Guan KL. Plouffe SW, et al. Among authors: guan kl. Trends Mol Med. 2015 Apr;21(4):212-22. doi: 10.1016/j.molmed.2015.01.003. Epub 2015 Feb 18. Trends Mol Med. 2015. PMID: 25702974 Free PMC article. Review.
YAP and TAZ: a nexus for Hippo signaling and beyond.
Hansen CG, Moroishi T, Guan KL. Hansen CG, et al. Among authors: guan kl. Trends Cell Biol. 2015 Sep;25(9):499-513. doi: 10.1016/j.tcb.2015.05.002. Epub 2015 Jun 2. Trends Cell Biol. 2015. PMID: 26045258 Free PMC article. Review.
441 results