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Spike residue 403 affects binding of coronavirus spikes to human ACE2.
Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F. Zech F, et al. Among authors: stenger s. Nat Commun. 2021 Nov 25;12(1):6855. doi: 10.1038/s41467-021-27180-0. Nat Commun. 2021. PMID: 34824253 Free PMC article.
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J. Wettstein L, et al. Among authors: stenger s. Nat Commun. 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0. Nat Commun. 2021. PMID: 33741941 Free PMC article.
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. Prelli Bozzo C, et al. Among authors: stenger s. Nat Commun. 2021 Jul 28;12(1):4584. doi: 10.1038/s41467-021-24817-y. Nat Commun. 2021. PMID: 34321474 Free PMC article.
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J, Kleger A. Krüger J, et al. Among authors: stenger s. Cell Mol Gastroenterol Hepatol. 2021;11(4):935-948. doi: 10.1016/j.jcmgh.2020.11.003. Epub 2020 Nov 10. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33186749 Free PMC article.
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. Müller JA, et al. Among authors: stenger s. Nat Metab. 2021 Feb;3(2):149-165. doi: 10.1038/s42255-021-00347-1. Epub 2021 Feb 3. Nat Metab. 2021. PMID: 33536639
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Hayn M, et al. Among authors: stenger s. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33974846 Free PMC article.
Detection of SARS-CoV-2 in human breastmilk.
Groß R, Conzelmann C, Müller JA, Stenger S, Steinhart K, Kirchhoff F, Münch J. Groß R, et al. Among authors: stenger s. Lancet. 2020 Jun 6;395(10239):1757-1758. doi: 10.1016/S0140-6736(20)31181-8. Epub 2020 May 21. Lancet. 2020. PMID: 32446324 Free PMC article. No abstract available.
An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection.
Conzelmann C, Gilg A, Groß R, Schütz D, Preising N, Ständker L, Jahrsdörfer B, Schrezenmeier H, Sparrer KMJ, Stamminger T, Stenger S, Münch J, Müller JA. Conzelmann C, et al. Among authors: stenger s. Antiviral Res. 2020 Sep;181:104882. doi: 10.1016/j.antiviral.2020.104882. Epub 2020 Jul 29. Antiviral Res. 2020. PMID: 32738255 Free PMC article.
Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection.
Schmidt H, Guthjahr L, Sauter A, Zech F, Nchioua R, Stenger S, Frick M, Kirchhoff F, Dietl P, Wittekindt OH. Schmidt H, et al. Among authors: stenger s. Am J Physiol Cell Physiol. 2022 Apr 1;322(4):C591-C604. doi: 10.1152/ajpcell.00363.2021. Epub 2022 Feb 23. Am J Physiol Cell Physiol. 2022. PMID: 35196166 Free PMC article.
135 results