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Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL-induced retinal pigment epithelial cell death as a potential pharmacotherapy.
Gnanaguru G, Mackey A, Choi EY, Arta A, Rossato FA, Gero TW, Urquhart AJ, Scott DA, D'Amore PA, Ng YSE. Gnanaguru G, et al. Among authors: gero tw. Free Radic Biol Med. 2022 Jan;178:360-368. doi: 10.1016/j.freeradbiomed.2021.11.026. Epub 2021 Nov 27. Free Radic Biol Med. 2022. PMID: 34843917 Free PMC article.
3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
Scott DA, Dakin LA, Del Valle DJ, Diebold RB, Drew L, Gero TW, Ogoe CA, Omer CA, Repik G, Thakur K, Ye Q, Zheng X. Scott DA, et al. Among authors: gero tw. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1382-4. doi: 10.1016/j.bmcl.2011.01.033. Epub 2011 Jan 14. Bioorg Med Chem Lett. 2011. PMID: 21295474
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS. Zeng M, et al. Among authors: gero tw. Cell Chem Biol. 2017 Aug 17;24(8):1005-1016.e3. doi: 10.1016/j.chembiol.2017.06.017. Epub 2017 Aug 3. Cell Chem Biol. 2017. PMID: 28781124 Free article.
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.
Zeng M, Xiong Y, Safaee N, Nowak RP, Donovan KA, Yuan CJ, Nabet B, Gero TW, Feru F, Li L, Gondi S, Ombelets LJ, Quan C, Jänne PA, Kostic M, Scott DA, Westover KD, Fischer ES, Gray NS. Zeng M, et al. Among authors: gero tw. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6. doi: 10.1016/j.chembiol.2019.12.006. Epub 2019 Dec 26. Cell Chem Biol. 2020. PMID: 31883964 Free article.
Benzopyrimidodiazepinone inhibitors of TNK2.
Groendyke BJ, Powell CE, Feru F, Gero TW, Li Z, Szabo H, Pang K, Feutrill J, Chen B, Li B, Gray NS, Scott DA. Groendyke BJ, et al. Among authors: gero tw. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126948. doi: 10.1016/j.bmcl.2020.126948. Epub 2020 Jan 7. Bioorg Med Chem Lett. 2020. PMID: 31928839
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. To C, et al. Among authors: gero tw. Nat Cancer. 2022 Apr;3(4):402-417. doi: 10.1038/s43018-022-00351-8. Epub 2022 Apr 14. Nat Cancer. 2022. PMID: 35422503 Free PMC article.
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma.
Hwang GH, Pazyra-Murphy MF, Seo HS, Dhe-Paganon S, Stopka SA, DiPiazza M, Sutter N, Gero TW, Volkert A, Ombelets L, Dittemore G, Rees MG, Ronan MM, Roth JA, Agar NYR, Scott DA, Segal RA. Hwang GH, et al. Among authors: gero tw. Cancer Res. 2024 Mar 15;84(6):872-886. doi: 10.1158/0008-5472.CAN-22-3784. Cancer Res. 2024. PMID: 38486486
23 results