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18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.
Jarr KU, Ye J, Kojima Y, Nanda V, Flores AM, Tsantilas P, Wang Y, Hosseini-Nassab N, Eberhard AV, Lotfi M, Käller M, Smith BR, Maegdefessel L, Leeper NJ. Jarr KU, et al. Among authors: eberhard av. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2821-2828. doi: 10.1161/ATVBAHA.120.315239. Epub 2020 Oct 22. Arterioscler Thromb Vasc Biol. 2020. PMID: 33086865 Free PMC article.
Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.
Wang Y, Nanda V, Direnzo D, Ye J, Xiao S, Kojima Y, Howe KL, Jarr KU, Flores AM, Tsantilas P, Tsao N, Rao A, Newman AAC, Eberhard AV, Priest JR, Ruusalepp A, Pasterkamp G, Maegdefessel L, Miller CL, Lind L, Koplev S, Björkegren JLM, Owens GK, Ingelsson E, Weissman IL, Leeper NJ. Wang Y, et al. Among authors: eberhard av. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15818-15826. doi: 10.1073/pnas.2006348117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541024 Free PMC article.
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis.
Jarr KU, Ye J, Kojima Y, Ye Z, Gao H, Schmid S, Luo L, Baylis RA, Lotfi M, Lopez N, Eberhard AV, Smith BR, Weissman IL, Maegdefessel L, Leeper NJ. Jarr KU, et al. Among authors: eberhard av. Nat Cardiovasc Res. 2022 Mar;1(3):253-262. doi: 10.1038/s44161-022-00023-x. Epub 2022 Mar 7. Nat Cardiovasc Res. 2022. PMID: 35990913 Free PMC article.