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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.
Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT, Buechner J, Garcia KC, Schumacher TN, van Veelen PA, Leisegang M, Jacobsen SEW, Woll P, Olweus J. Ali M, et al. Among authors: leisegang m. Nat Biotechnol. 2022 Apr;40(4):488-498. doi: 10.1038/s41587-021-01089-x. Epub 2021 Dec 6. Nat Biotechnol. 2022. PMID: 34873326 Free PMC article.
A systematic safety pipeline for selection of T-cell receptors to enter clinical use.
Foldvari Z, Knetter C, Yang W, Gjerdingen TJ, Bollineni RC, Tran TT, Lund-Johansen F, Kolstad A, Drousch K, Klopfleisch R, Leisegang M, Olweus J. Foldvari Z, et al. Among authors: leisegang m. NPJ Vaccines. 2023 Aug 22;8(1):126. doi: 10.1038/s41541-023-00713-y. NPJ Vaccines. 2023. PMID: 37607971 Free PMC article.
Designer T cells by T cell receptor replacement.
Sommermeyer D, Neudorfer J, Weinhold M, Leisegang M, Engels B, Noessner E, Heemskerk MH, Charo J, Schendel DJ, Blankenstein T, Bernhard H, Uckert W. Sommermeyer D, et al. Among authors: leisegang m. Eur J Immunol. 2006 Nov;36(11):3052-9. doi: 10.1002/eji.200636539. Eur J Immunol. 2006. PMID: 17051621 Free article.
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Spranger S, Jeremias I, Wilde S, Leisegang M, Stärck L, Mosetter B, Uckert W, Heemskerk MH, Schendel DJ, Frankenberger B. Spranger S, et al. Among authors: leisegang m. Blood. 2012 Apr 12;119(15):3440-9. doi: 10.1182/blood-2011-06-357939. Epub 2012 Feb 27. Blood. 2012. PMID: 22371883 Free article.
100 results