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Superhuman cell death detection with biomarker-optimized neural networks.
Linsley JW, Linsley DA, Lamstein J, Ryan G, Shah K, Castello NA, Oza V, Kalra J, Wang S, Tokuno Z, Javaherian A, Serre T, Finkbeiner S. Linsley JW, et al. Sci Adv. 2021 Dec 10;7(50):eabf8142. doi: 10.1126/sciadv.abf8142. Epub 2021 Dec 8. Sci Adv. 2021. PMID: 34878844 Free PMC article.
Cell death assays for neurodegenerative disease drug discovery.
Linsley JW, Reisine T, Finkbeiner S. Linsley JW, et al. Expert Opin Drug Discov. 2019 Sep;14(9):901-913. doi: 10.1080/17460441.2019.1623784. Epub 2019 Jun 10. Expert Opin Drug Discov. 2019. PMID: 31179783 Free PMC article. Review.
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Fang MY, et al. Among authors: linsley jw. Neuron. 2019 Sep 4;103(5):802-819.e11. doi: 10.1016/j.neuron.2019.05.048. Epub 2019 Jul 1. Neuron. 2019. PMID: 31272829 Free PMC article.
Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3.
Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY. Linsley JW, et al. Among authors: linsley d. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E228-E236. doi: 10.1073/pnas.1619238114. Epub 2016 Dec 21. Proc Natl Acad Sci U S A. 2017. PMID: 28003463 Free PMC article.
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
Horstick EJ, Linsley JW, Dowling JJ, Hauser MA, McDonald KK, Ashley-Koch A, Saint-Amant L, Satish A, Cui WW, Zhou W, Sprague SM, Stamm DS, Powell CM, Speer MC, Franzini-Armstrong C, Hirata H, Kuwada JY. Horstick EJ, et al. Among authors: linsley jw. Nat Commun. 2013;4:1952. doi: 10.1038/ncomms2952. Nat Commun. 2013. PMID: 23736855 Free PMC article.
Stac protein regulates release of neuropeptides.
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Hsu IU, et al. Among authors: linsley jw. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29914-29924. doi: 10.1073/pnas.2009224117. Epub 2020 Nov 9. Proc Natl Acad Sci U S A. 2020. PMID: 33168737 Free PMC article.
13 results