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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Gulluni F, et al. Among authors: ghigo a. Science. 2021 Dec 10;374(6573):eabk0410. doi: 10.1126/science.abk0410. Epub 2021 Dec 10. Science. 2021. PMID: 34882480 Free PMC article.
In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury.
Federti E, Matte A, Recchiuti A, Garello F, Ghigo A, El Nemer W, Terreno E, Amoresano A, Mattoscio D, Turrini F, Lebouef C, Janin A, Pantaleo A, Russo R, Marin M, Iatcencko I, Riccardi V, Siciliano A, Iolascon A, Brugnara C, De Franceschi L. Federti E, et al. Among authors: ghigo a. Hemasphere. 2023 Feb 28;7(3):e848. doi: 10.1097/HS9.0000000000000848. eCollection 2023 Mar. Hemasphere. 2023. PMID: 36874380 Free PMC article.
MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation.
Schirone L, Vecchio D, Valenti V, Forte M, Relucenti M, Angelini A, Zaglia T, Schiavon S, D'Ambrosio L, Sarto G, Stanzione R, Mangione E, Miglietta S, Di Bona A, Fedrigo M, Ghigo A, Versaci F, Petrozza V, Marchitti S, Rubattu S, Volpe M, Sadoshima J, Frati L, Frati G, Sciarretta S. Schirone L, et al. Among authors: ghigo a. Cell Mol Life Sci. 2023 Aug 11;80(9):245. doi: 10.1007/s00018-023-04877-7. Cell Mol Life Sci. 2023. PMID: 37566283 Free PMC article.
Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice.
Liu J, Lane S, Lall R, Russo M, Farrell L, Debreli Coskun M, Curtin C, Araujo-Gutierrez R, Scherrer-Crosbie M, Trachtenberg BH, Kim J, Tolosano E, Ghigo A, Gerszten RE, Asnani A. Liu J, et al. Among authors: ghigo a. Sci Adv. 2022 Dec 23;8(51):eadc9245. doi: 10.1126/sciadv.adc9245. Epub 2022 Dec 23. Sci Adv. 2022. PMID: 36563141 Free PMC article.
Taming the PI3K team to hold inflammation and cancer at bay.
Hirsch E, Ciraolo E, Ghigo A, Costa C. Hirsch E, et al. Among authors: ghigo a. Pharmacol Ther. 2008 May;118(2):192-205. doi: 10.1016/j.pharmthera.2008.02.004. Epub 2008 Mar 5. Pharmacol Ther. 2008. PMID: 18420279 Review.
Phosphoinositide 3-kinases in health and disease.
Ghigo A, Morello F, Perino A, Hirsch E. Ghigo A, et al. Subcell Biochem. 2012;58:183-213. doi: 10.1007/978-94-007-3012-0_6. Subcell Biochem. 2012. PMID: 22403077 Review.
125 results