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Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology.
J Infect Dis. 2022 Feb 1;225(3):404-412. doi: 10.1093/infdis/jiab594.
J Infect Dis. 2022.
PMID: 34893851
Free PMC article.
Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding.
Dempsey R, Tamburrino G, Schewe KE, Crowe J, Nuccitelli A, Dibben O.
Dempsey R, et al. Among authors: schewe ke.
PLoS Pathog. 2022 May 27;18(5):e1010585. doi: 10.1371/journal.ppat.1010585. eCollection 2022 May.
PLoS Pathog. 2022.
PMID: 35622874
Free PMC article.
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Defining the root cause of reduced H1N1 live attenuated influenza vaccine effectiveness: low viral fitness leads to inter-strain competition.
Dibben O, Crowe J, Cooper S, Hill L, Schewe KE, Bright H.
Dibben O, et al. Among authors: schewe ke.
NPJ Vaccines. 2021 Mar 12;6(1):35. doi: 10.1038/s41541-021-00300-z.
NPJ Vaccines. 2021.
PMID: 33712628
Free PMC article.
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In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Lucas S, Heim R, Ries C, Schewe KE, Birk B, Hartmann RW.
Lucas S, et al. Among authors: schewe ke.
J Med Chem. 2008 Dec 25;51(24):8077-87. doi: 10.1021/jm800888q.
J Med Chem. 2008.
PMID: 19049427
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Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Lucas S, Heim R, Negri M, Antes I, Ries C, Schewe KE, Bisi A, Gobbi S, Hartmann RW.
Lucas S, et al. Among authors: schewe ke.
J Med Chem. 2008 Oct 9;51(19):6138-49. doi: 10.1021/jm800683c. Epub 2008 Sep 3.
J Med Chem. 2008.
PMID: 18763754
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Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Heim R, Lucas S, Grombein CM, Ries C, Schewe KE, Negri M, Müller-Vieira U, Birk B, Hartmann RW.
Heim R, et al. Among authors: schewe ke.
J Med Chem. 2008 Aug 28;51(16):5064-74. doi: 10.1021/jm800377h. Epub 2008 Aug 1.
J Med Chem. 2008.
PMID: 18672861
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Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.
Gobbi S, Cavalli A, Negri M, Schewe KE, Belluti F, Piazzi L, Hartmann RW, Recanatini M, Bisi A.
Gobbi S, et al. Among authors: schewe ke.
J Med Chem. 2007 Jul 26;50(15):3420-2. doi: 10.1021/jm0702938. Epub 2007 Jun 22.
J Med Chem. 2007.
PMID: 17585752
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