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Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Hertzog J, et al. Among authors: rehwinkel j. Eur J Immunol. 2018 Jul;48(7):1120-1136. doi: 10.1002/eji.201847483. Epub 2018 Apr 6. Eur J Immunol. 2018. PMID: 29572905 Free PMC article.
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.
Dias Junior AG, Sampaio NG, Rehwinkel J. Dias Junior AG, et al. Among authors: rehwinkel j. Trends Microbiol. 2019 Jan;27(1):75-85. doi: 10.1016/j.tim.2018.08.007. Epub 2018 Sep 7. Trends Microbiol. 2019. PMID: 30201512 Free PMC article. Review.
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Maelfait J, Liverpool L, Bridgeman A, Ragan KB, Upton JW, Rehwinkel J. Maelfait J, et al. Among authors: rehwinkel j. EMBO J. 2017 Sep 1;36(17):2529-2543. doi: 10.15252/embj.201796476. Epub 2017 Jul 17. EMBO J. 2017. PMID: 28716805 Free PMC article.
Mitochondrial double-stranded RNA triggers antiviral signalling in humans.
Dhir A, Dhir S, Borowski LS, Jimenez L, Teitell M, Rötig A, Crow YJ, Rice GI, Duffy D, Tamby C, Nojima T, Munnich A, Schiff M, de Almeida CR, Rehwinkel J, Dziembowski A, Szczesny RJ, Proudfoot NJ. Dhir A, et al. Among authors: rehwinkel j. Nature. 2018 Aug;560(7717):238-242. doi: 10.1038/s41586-018-0363-0. Epub 2018 Jul 25. Nature. 2018. PMID: 30046113 Free PMC article.
Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.
Fraser E, Denney L, Antanaviciute A, Blirando K, Vuppusetty C, Zheng Y, Repapi E, Iotchkova V, Taylor S, Ashley N, St Noble V, Benamore R, Hoyles R, Clelland C, Rastrick JMD, Hardman CS, Alham NK, Rigby RE, Simmons A, Rehwinkel J, Ho LP. Fraser E, et al. Among authors: rehwinkel j. Front Immunol. 2021 Mar 5;12:623430. doi: 10.3389/fimmu.2021.623430. eCollection 2021. Front Immunol. 2021. PMID: 33746960 Free PMC article.
The RNA sensor MDA5 detects SARS-CoV-2 infection.
Sampaio NG, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen JP, Dupont M, Russell RA, Noerenberg M, Rehwinkel J. Sampaio NG, et al. Among authors: rehwinkel j. Sci Rep. 2021 Jul 1;11(1):13638. doi: 10.1038/s41598-021-92940-3. Sci Rep. 2021. PMID: 34211037 Free PMC article.
91 results