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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.
Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD. Liu L, et al. Among authors: reddem er. Immunity. 2023 Oct 10;56(10):2442-2455.e8. doi: 10.1016/j.immuni.2023.09.003. Epub 2023 Sep 29. Immunity. 2023. PMID: 37776849 Free PMC article.
Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking.
Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD. Liu L, et al. Among authors: reddem er. bioRxiv [Preprint]. 2023 Apr 10:2023.04.08.536123. doi: 10.1101/2023.04.08.536123. bioRxiv. 2023. PMID: 37090592 Free PMC article. Preprint.
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses.
Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD. Liu L, et al. Among authors: reddem er. Sci Transl Med. 2022 May 25;14(646):eabn6859. doi: 10.1126/scitranslmed.abn6859. Epub 2022 May 25. Sci Transl Med. 2022. PMID: 35438546 Free PMC article.
Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2.
Fukudome A, Singh J, Mishra V, Reddem E, Martinez-Marquez F, Wenzel S, Yan R, Shiozaki M, Yu Z, Wang JC, Takagi Y, Pikaard CS. Fukudome A, et al. Among authors: reddem e. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2115899118. doi: 10.1073/pnas.2115899118. Proc Natl Acad Sci U S A. 2021. PMID: 34903670 Free PMC article.
Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS-CoV-2.
Madan B, Reddem ER, Wang P, Casner RG, Nair MS, Huang Y, Fahad AS, de Souza MO, Banach BB, López Acevedo SN, Pan X, Nimrania R, Teng IT, Bahna F, Zhou T, Zhang B, Yin MT, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Madan B, et al. Among authors: reddem er. AIChE J. 2021 Dec;67(12):e17440. doi: 10.1002/aic.17440. Epub 2021 Oct 4. AIChE J. 2021. PMID: 34898670 Free PMC article.
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses.
Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Banach BB, et al. Among authors: reddem er. Cell Rep. 2021 Oct 5;37(1):109771. doi: 10.1016/j.celrep.2021.109771. Epub 2021 Sep 28. Cell Rep. 2021. PMID: 34587480 Free PMC article.
20 results