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Broadly neutralizing antibodies target a haemagglutinin anchor epitope.
Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O'Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC. Guthmiller JJ, et al. Among authors: ward ab. Nature. 2022 Feb;602(7896):314-320. doi: 10.1038/s41586-021-04356-8. Epub 2021 Dec 23. Nature. 2022. PMID: 34942633 Free PMC article.
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA, Sanders RW. Sliepen K, et al. Among authors: ward ab. Nat Commun. 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5. Nat Commun. 2019. PMID: 31142746 Free PMC article.
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, Behrens AJ, Catalano M, Del Moral-Sánchez I, Ketas TJ, LaBranche C, van Gils MJ, Sliepen K, Stewart LJ, Crispin M, Montefiori DC, Baker D, Moore JP, Klasse PJ, Ward AB, King NP, Sanders RW. Brouwer PJM, et al. Among authors: ward ab. Nat Commun. 2019 Sep 19;10(1):4272. doi: 10.1038/s41467-019-12080-1. Nat Commun. 2019. PMID: 31537780 Free PMC article.
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR. Steichen JM, et al. Among authors: ward ab. Science. 2019 Dec 6;366(6470):eaax4380. doi: 10.1126/science.aax4380. Epub 2019 Oct 31. Science. 2019. PMID: 31672916 Free PMC article.
An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS; IAVI Protocol G Investigators; Poignard P, Burton DR, Murrell B, Ward AB, Zhu J, Wilson IA, Zwick MB. Zhang L, et al. Among authors: ward ab. Nat Commun. 2019 Nov 26;10(1):5389. doi: 10.1038/s41467-019-12973-1. Nat Commun. 2019. PMID: 31772165 Free PMC article.
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation.
Watanabe Y, Berndsen ZT, Raghwani J, Seabright GE, Allen JD, Pybus OG, McLellan JS, Wilson IA, Bowden TA, Ward AB, Crispin M. Watanabe Y, et al. Among authors: ward ab. Nat Commun. 2020 May 27;11(1):2688. doi: 10.1038/s41467-020-16567-0. Nat Commun. 2020. PMID: 32461612 Free PMC article.
Structural basis of broad HIV neutralization by a vaccine-induced cow antibody.
Stanfield RL, Berndsen ZT, Huang R, Sok D, Warner G, Torres JL, Burton DR, Ward AB, Wilson IA, Smider VV. Stanfield RL, et al. Among authors: ward ab. Sci Adv. 2020 May 27;6(22):eaba0468. doi: 10.1126/sciadv.aba0468. eCollection 2020 May. Sci Adv. 2020. PMID: 32518821 Free PMC article.
471 results