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Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Shyam M, Verma H, Bhattacharje G, Mukherjee P, Singh S, Kamilya S, Jalani P, Das S, Dasgupta A, Mondal A, Das AK, Singh A, Brucoli F, Bagnéris C, Dickman R, Basavanakatti VN, Naresh Babu P, Sankaran V, Dev A, Sinha BN, Bhakta S, Jayaprakash V. Shyam M, et al. Among authors: dasgupta a. J Med Chem. 2022 Jan 13;65(1):234-256. doi: 10.1021/acs.jmedchem.1c01349. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34981940
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Singh S, Roy KK, Khan SR, Kashyap VK, Sharma A, Jaiswal S, Sharma SK, Krishnan MY, Chaturvedi V, Lal J, Sinha S, Dasgupta A, Srivastava R, Saxena AK. Singh S, et al. Among authors: dasgupta a. Bioorg Med Chem. 2015 Feb 15;23(4):742-52. doi: 10.1016/j.bmc.2014.12.060. Epub 2015 Jan 2. Bioorg Med Chem. 2015. PMID: 25614114
Repurposing Ivacaftor for treatment of Staphylococcus aureus infections.
Thakare R, Singh AK, Das S, Vasudevan N, Jachak GR, Reddy DS, Dasgupta A, Chopra S. Thakare R, et al. Among authors: dasgupta a. Int J Antimicrob Agents. 2017 Sep;50(3):389-392. doi: 10.1016/j.ijantimicag.2017.03.020. Epub 2017 Jul 8. Int J Antimicrob Agents. 2017. PMID: 28694231
Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress.
Karade SS, Pandey S, Ansari A, Das S, Tripathi S, Arora A, Chopra S, Pratap JV, Dasgupta A. Karade SS, et al. Among authors: dasgupta a. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):317-330. doi: 10.1016/j.bbapap.2018.10.011. Epub 2018 Oct 17. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30342240
Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial.
Kumar A, Boradia VM, Thakare R, Singh AK, Gani Z, Das S, Patidar A, Dasgupta A, Chopra S, Raje M, Raje CI. Kumar A, et al. Among authors: dasgupta a. J Antimicrob Chemother. 2019 Apr 1;74(4):912-920. doi: 10.1093/jac/dky555. J Antimicrob Chemother. 2019. PMID: 30689890 Free PMC article.
1,632 results