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Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Shyam M, Verma H, Bhattacharje G, Mukherjee P, Singh S, Kamilya S, Jalani P, Das S, Dasgupta A, Mondal A, Das AK, Singh A, Brucoli F, Bagnéris C, Dickman R, Basavanakatti VN, Naresh Babu P, Sankaran V, Dev A, Sinha BN, Bhakta S, Jayaprakash V. Shyam M, et al. Among authors: singh s, singh a. J Med Chem. 2022 Jan 13;65(1):234-256. doi: 10.1021/acs.jmedchem.1c01349. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34981940
Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics.
Shyam M, Bhattacharje G, Daniel C, Kumar A, Yadav P, Mukherjee P, Singh S, Das AK, Narender T, Singh A, Jayaprakash V, Bhakta S. Shyam M, et al. Among authors: singh s, singh a. Molecules. 2023 Dec 15;28(24):8115. doi: 10.3390/molecules28248115. Molecules. 2023. PMID: 38138601 Free PMC article.
Nitrofuranyl Methyl Piperazines as New Anti-TB Agents: Identification, Validation, Medicinal Chemistry, and PK Studies.
Yempalla KR, Munagala G, Singh S, Magotra A, Kumar S, Rajput VS, Bharate SS, Tikoo M, Singh GD, Khan IA, Vishwakarma RA, Singh PP. Yempalla KR, et al. Among authors: singh gd, singh pp, singh s. ACS Med Chem Lett. 2015 Aug 31;6(10):1041-6. doi: 10.1021/acsmedchemlett.5b00141. eCollection 2015 Oct 8. ACS Med Chem Lett. 2015. PMID: 26487909 Free PMC article.
Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species.
Shee S, Singh S, Tripathi A, Thakur C, Kumar T A, Das M, Yadav V, Kohli S, Rajmani RS, Chandra N, Chakrapani H, Drlica K, Singh A. Shee S, et al. Among authors: singh s, singh a. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0059222. doi: 10.1128/aac.00592-22. Epub 2022 Aug 17. Antimicrob Agents Chemother. 2022. PMID: 35975988 Free PMC article.
Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation.
Munagala G, Yempalla KR, Singh S, Sharma S, Kalia NP, Rajput VS, Kumar S, Sawant SD, Khan IA, Vishwakarma RA, Singh PP. Munagala G, et al. Among authors: singh pp, singh s. Org Biomol Chem. 2015 Mar 28;13(12):3610-24. doi: 10.1039/c5ob00054h. Org Biomol Chem. 2015. PMID: 25670502
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