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CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. Affandi AJ, et al. Among authors: carvalheiro t. Cell Rep. 2022 Jan 4;38(1):110189. doi: 10.1016/j.celrep.2021.110189. Cell Rep. 2022. PMID: 34986347 Free article.
Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis.
Chouri E, Servaas NH, Bekker CPJ, Affandi AJ, Cossu M, Hillen MR, Angiolilli C, Mertens JS, van den Hoogen LL, Silva-Cardoso S, van der Kroef M, Vazirpanah N, Wichers CGK, Carvalheiro T, Blokland SLM, Giovannone B, Porretti L, Marut W, Vigone B, van Roon JAG, Beretta L, Rossato M, Radstake TRDJ. Chouri E, et al. Among authors: carvalheiro t. J Autoimmun. 2018 May;89:162-170. doi: 10.1016/j.jaut.2017.12.015. Epub 2018 Jan 20. J Autoimmun. 2018. PMID: 29371048 Free article.
Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis.
Carvalheiro T, Affandi AJ, Malvar-Fernández B, Dullemond I, Cossu M, Ottria A, Mertens JS, Giovannone B, Bonte-Mineur F, Kok MR, Marut W, Reedquist KA, Radstake TR, García S. Carvalheiro T, et al. Arthritis Rheumatol. 2019 Oct;71(10):1711-1722. doi: 10.1002/art.40915. Epub 2019 Aug 27. Arthritis Rheumatol. 2019. PMID: 31012544 Free PMC article.
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis.
Affandi AJ, Carvalheiro T, Ottria A, Broen JC, Bossini-Castillo L, Tieland RG, Bon LV, Chouri E, Rossato M, Mertens JS, Garcia S, Pandit A, de Kroon LM, Christmann RB, Martin J, van Roon JA, Radstake TR, Marut W. Affandi AJ, et al. Among authors: carvalheiro t. Ann Rheum Dis. 2019 Sep;78(9):1249-1259. doi: 10.1136/annrheumdis-2018-214991. Epub 2019 May 24. Ann Rheum Dis. 2019. PMID: 31126957
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.
Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W. Ottria A, et al. Among authors: carvalheiro t. Rheumatology (Oxford). 2022 May 30;61(6):2682-2693. doi: 10.1093/rheumatology/keab532. Rheumatology (Oxford). 2022. PMID: 34559222
CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.
van der Kroef M, Carvalheiro T, Rossato M, de Wit F, Cossu M, Chouri E, Wichers CGK, Bekker CPJ, Beretta L, Vazirpanah N, Trombetta E, Radstake TRDJ, Angiolilli C. van der Kroef M, et al. Among authors: carvalheiro t. J Autoimmun. 2020 Jul;111:102444. doi: 10.1016/j.jaut.2020.102444. Epub 2020 Apr 10. J Autoimmun. 2020. PMID: 32284212 Free article.
Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis.
Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, Ottria A, Chouri E, Affandi AJ, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake TRDJ, Andeweg AC, Pandit A. Servaas NH, et al. Among authors: carvalheiro t. J Autoimmun. 2021 Feb;117:102574. doi: 10.1016/j.jaut.2020.102574. Epub 2020 Dec 8. J Autoimmun. 2021. PMID: 33307312 Free article.
44 results