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The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.
Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. Xu Y, et al. Among authors: molosh ai. J Biol Chem. 2020 Mar 13;295(11):3614-3634. doi: 10.1074/jbc.RA119.011527. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953327 Free PMC article.
Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2).
Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R. Brittain JM, et al. Among authors: molosh ai. J Biol Chem. 2011 Oct 28;286(43):37778-92. doi: 10.1074/jbc.M111.255455. Epub 2011 Aug 9. J Biol Chem. 2011. PMID: 21832084 Free PMC article.
From bedside to bench and back: Translating ASD models.
Drozd HP, Karathanasis SF, Molosh AI, Lukkes JL, Clapp DW, Shekhar A. Drozd HP, et al. Among authors: molosh ai. Prog Brain Res. 2018;241:113-158. doi: 10.1016/bs.pbr.2018.10.003. Epub 2018 Nov 7. Prog Brain Res. 2018. PMID: 30447753 Review.
Using loss- and gain-of-function approaches to target amygdala-projecting serotonergic neurons in the dorsal raphe nucleus that enhance anxiety-related and conditioned fear behaviors.
Bernabe CS, Caliman IF, Truitt WA, Molosh AI, Lowry CA, Hay-Schmidt A, Shekhar A, Johnson PL. Bernabe CS, et al. Among authors: molosh ai. J Psychopharmacol. 2020 Apr;34(4):400-411. doi: 10.1177/0269881119900981. Epub 2020 Mar 10. J Psychopharmacol. 2020. PMID: 32153226 Free PMC article.
29 results