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Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality.
Lobritz MA, Andrews IW, Braff D, Porter CBM, Gutierrez A, Furuta Y, Cortes LBG, Ferrante T, Bening SC, Wong F, Gruber C, Bakerlee CW, Lambert G, Walker GC, Dwyer DJ, Collins JJ. Lobritz MA, et al. Among authors: dwyer dj. Cell Chem Biol. 2022 Feb 17;29(2):276-286.e4. doi: 10.1016/j.chembiol.2021.12.010. Epub 2022 Jan 5. Cell Chem Biol. 2022. PMID: 34990601 Free PMC article.
Antibiotic efficacy is linked to bacterial cellular respiration.
Lobritz MA, Belenky P, Porter CB, Gutierrez A, Yang JH, Schwarz EG, Dwyer DJ, Khalil AS, Collins JJ. Lobritz MA, et al. Among authors: dwyer dj. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8173-80. doi: 10.1073/pnas.1509743112. Epub 2015 Jun 22. Proc Natl Acad Sci U S A. 2015. PMID: 26100898 Free PMC article.
Antibiotics induce redox-related physiological alterations as part of their lethality.
Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CT, Lobritz MA, Braff D, Schwarz EG, Ye JD, Pati M, Vercruysse M, Ralifo PS, Allison KR, Khalil AS, Ting AY, Walker GC, Collins JJ. Dwyer DJ, et al. Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2100-9. doi: 10.1073/pnas.1401876111. Epub 2014 May 6. Proc Natl Acad Sci U S A. 2014. PMID: 24803433 Free PMC article.
How antibiotics kill bacteria: from targets to networks.
Kohanski MA, Dwyer DJ, Collins JJ. Kohanski MA, et al. Among authors: dwyer dj. Nat Rev Microbiol. 2010 Jun;8(6):423-35. doi: 10.1038/nrmicro2333. Epub 2010 May 4. Nat Rev Microbiol. 2010. PMID: 20440275 Free PMC article. Review.
28 results