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Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality.
Lobritz MA, Andrews IW, Braff D, Porter CBM, Gutierrez A, Furuta Y, Cortes LBG, Ferrante T, Bening SC, Wong F, Gruber C, Bakerlee CW, Lambert G, Walker GC, Dwyer DJ, Collins JJ. Lobritz MA, et al. Cell Chem Biol. 2022 Feb 17;29(2):276-286.e4. doi: 10.1016/j.chembiol.2021.12.010. Epub 2022 Jan 5. Cell Chem Biol. 2022. PMID: 34990601 Free PMC article.
Antibiotic efficacy is linked to bacterial cellular respiration.
Lobritz MA, Belenky P, Porter CB, Gutierrez A, Yang JH, Schwarz EG, Dwyer DJ, Khalil AS, Collins JJ. Lobritz MA, et al. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8173-80. doi: 10.1073/pnas.1509743112. Epub 2015 Jun 22. Proc Natl Acad Sci U S A. 2015. PMID: 26100898 Free PMC article.
Bacterial Metabolism and Antibiotic Efficacy.
Stokes JM, Lopatkin AJ, Lobritz MA, Collins JJ. Stokes JM, et al. Among authors: lobritz ma. Cell Metab. 2019 Aug 6;30(2):251-259. doi: 10.1016/j.cmet.2019.06.009. Epub 2019 Jul 3. Cell Metab. 2019. PMID: 31279676 Free PMC article. Review.
Antibiotics induce redox-related physiological alterations as part of their lethality.
Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CT, Lobritz MA, Braff D, Schwarz EG, Ye JD, Pati M, Vercruysse M, Ralifo PS, Allison KR, Khalil AS, Ting AY, Walker GC, Collins JJ. Dwyer DJ, et al. Among authors: lobritz ma. Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2100-9. doi: 10.1073/pnas.1401876111. Epub 2014 May 6. Proc Natl Acad Sci U S A. 2014. PMID: 24803433 Free PMC article.
Microbial persistence and the road to drug resistance.
Cohen NR, Lobritz MA, Collins JJ. Cohen NR, et al. Among authors: lobritz ma. Cell Host Microbe. 2013 Jun 12;13(6):632-42. doi: 10.1016/j.chom.2013.05.009. Cell Host Microbe. 2013. PMID: 23768488 Free PMC article. Review.
Low neutralizing antibody titers after asymptomatic or non-severe SARS-CoV-2 infection over a 6-month assessment period.
Lazor-Blanchet C, Zygoura P, Dafni U, Lamoth F, Tsourti Z, Lobritz MA, Regina J, Grandbastien B, Fenwick C, Pantaleo G, Calandra T, Meylan S. Lazor-Blanchet C, et al. Among authors: lobritz ma. J Infect. 2022 May;84(5):722-746. doi: 10.1016/j.jinf.2022.02.001. Epub 2022 Feb 5. J Infect. 2022. PMID: 35134464 Free PMC article. No abstract available.
31 results