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Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality.
Lobritz MA, Andrews IW, Braff D, Porter CBM, Gutierrez A, Furuta Y, Cortes LBG, Ferrante T, Bening SC, Wong F, Gruber C, Bakerlee CW, Lambert G, Walker GC, Dwyer DJ, Collins JJ. Lobritz MA, et al. Among authors: walker gc. Cell Chem Biol. 2022 Feb 17;29(2):276-286.e4. doi: 10.1016/j.chembiol.2021.12.010. Epub 2022 Jan 5. Cell Chem Biol. 2022. PMID: 34990601 Free PMC article.
Unraveling the physiological complexities of antibiotic lethality.
Dwyer DJ, Collins JJ, Walker GC. Dwyer DJ, et al. Among authors: walker gc. Annu Rev Pharmacol Toxicol. 2015;55:313-32. doi: 10.1146/annurev-pharmtox-010814-124712. Epub 2014 Sep 10. Annu Rev Pharmacol Toxicol. 2015. PMID: 25251995 Review.
Antibiotics induce redox-related physiological alterations as part of their lethality.
Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CT, Lobritz MA, Braff D, Schwarz EG, Ye JD, Pati M, Vercruysse M, Ralifo PS, Allison KR, Khalil AS, Ting AY, Walker GC, Collins JJ. Dwyer DJ, et al. Among authors: walker gc. Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2100-9. doi: 10.1073/pnas.1401876111. Epub 2014 May 6. Proc Natl Acad Sci U S A. 2014. PMID: 24803433 Free PMC article.
A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action.
Yang JH, Wright SN, Hamblin M, McCloskey D, Alcantar MA, Schrübbers L, Lopatkin AJ, Satish S, Nili A, Palsson BO, Walker GC, Collins JJ. Yang JH, et al. Among authors: walker gc. Cell. 2019 May 30;177(6):1649-1661.e9. doi: 10.1016/j.cell.2019.04.016. Epub 2019 May 9. Cell. 2019. PMID: 31080069 Free PMC article.
555 results