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Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
JAMA Psychiatry. 2022 Mar 1;79(3):260-269. doi: 10.1001/jamapsychiatry.2021.3799.
JAMA Psychiatry. 2022.
PMID: 35019943
Free PMC article.
Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort.
Grama S, Willcocks I, Hubert JJ, Pardiñas AF, Legge SE, Bracher-Smith M, Menzies GE, Hall LS, Pocklington AJ, Anney RJL, Bray NJ, Escott-Price V, Caseras X.
Grama S, et al.
Transl Psychiatry. 2020 Sep 9;10(1):309. doi: 10.1038/s41398-020-00940-0.
Transl Psychiatry. 2020.
PMID: 32908133
Free PMC article.
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Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia.
Willcocks IR, Legge SE, Nalmpanti M, Mazzeo L, King A, Jansen J, Helthuis M, Owen MJ, O'Donovan MC, Walters JTR, Pardiñas AF.
Willcocks IR, et al.
Front Pharmacol. 2021 Apr 16;12:658734. doi: 10.3389/fphar.2021.658734. eCollection 2021.
Front Pharmacol. 2021.
PMID: 33959025
Free PMC article.
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Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores.
Kappel DB, Legge SE, Hubbard L, Willcocks IR, O'Connell KS, Smith RL, Molden E, Andreassen OA, King A, Jansen J, Helthuis M, Owen MJ, O'Donovan MC, Walters JTR, Pardiñas AF.
Kappel DB, et al. Among authors: willcocks ir.
Biol Psychiatry. 2023 Jan 15;93(2):149-156. doi: 10.1016/j.biopsych.2022.07.014. Epub 2022 Aug 5.
Biol Psychiatry. 2023.
PMID: 36244804
Free PMC article.
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Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count.
Lock SK, Legge SE, Kappel DB, Willcocks IR, Helthuis M, Jansen J, Walters JTR, Owen MJ, O'Donovan MC, Pardiñas AF.
Lock SK, et al. Among authors: willcocks ir.
Schizophrenia (Heidelb). 2023 Oct 18;9(1):74. doi: 10.1038/s41537-023-00404-6.
Schizophrenia (Heidelb). 2023.
PMID: 37853043
Free PMC article.
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