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Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism.
Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Usluer S, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A. Krstic J, et al. Among authors: prokesch a. Sci Adv. 2022 Jan 21;8(3):eabh2635. doi: 10.1126/sciadv.abh2635. Epub 2022 Jan 21. Sci Adv. 2022. PMID: 35061544 Free PMC article.
NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas.
Deutsch AJ, Rinner B, Wenzl K, Pichler M, Troppan K, Steinbauer E, Schwarzenbacher D, Reitter S, Feichtinger J, Tierling S, Prokesch A, Scheideler M, Krogsdam A, Thallinger GG, Schaider H, Beham-Schmid C, Neumeister P. Deutsch AJ, et al. Among authors: prokesch a. Blood. 2014 Apr 10;123(15):2367-77. doi: 10.1182/blood-2013-08-518878. Epub 2014 Feb 19. Blood. 2014. PMID: 24553175 Free article.
Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.
Rossmann C, Windpassinger C, Brunner D, Kovacevic A, Schweighofer N, Malli R, Schuligoi R, Prokesch A, Kluve-Beckerman B, Graier WF, Kratky D, Sattler W, Malle E. Rossmann C, et al. Among authors: prokesch a. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1643-9. doi: 10.1016/j.bbrc.2014.07.054. Epub 2014 Jul 17. Biochem Biophys Res Commun. 2014. PMID: 25044109 Free PMC article.
Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.
Prokesch A, Graef FA, Madl T, Kahlhofer J, Heidenreich S, Schumann A, Moyschewitz E, Pristoynik P, Blaschitz A, Knauer M, Muenzner M, Bogner-Strauss JG, Dohr G, Schulz TJ, Schupp M. Prokesch A, et al. FASEB J. 2017 Feb;31(2):732-742. doi: 10.1096/fj.201600845R. Epub 2016 Nov 3. FASEB J. 2017. PMID: 27811061 Free PMC article.
Here we report a previously unrecognized role of the tumor suppressor p53 in the physiologic adaptation to food withdrawal. ...Because of its tumor suppressor function, p53 stabilization by starvation could have implications for both metabolic and oncological diseases of t …
Here we report a previously unrecognized role of the tumor suppressor p53 in the physiologic adaptation to food withdrawal. ...Becaus …
NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes.
Deutsch AJA, Rinner B, Pichler M, Prochazka K, Pansy K, Bischof M, Fechter K, Hatzl S, Feichtinger J, Wenzl K, Frisch MT, Stiegelbauer V, Prokesch A, Krogsdam A, Sill H, Thallinger GG, Greinix HT, Wang C, Beham-Schmid C, Neumeister P. Deutsch AJA, et al. Among authors: prokesch a. Cancer Res. 2017 May 1;77(9):2375-2386. doi: 10.1158/0008-5472.CAN-16-2320. Epub 2017 Mar 1. Cancer Res. 2017. PMID: 28249906
Downregulation of p53 drives autophagy during human trophoblast differentiation.
Gauster M, Maninger S, Siwetz M, Deutsch A, El-Heliebi A, Kolb-Lenz D, Hiden U, Desoye G, Herse F, Prokesch A. Gauster M, et al. Among authors: prokesch a. Cell Mol Life Sci. 2018 May;75(10):1839-1855. doi: 10.1007/s00018-017-2695-6. Epub 2017 Oct 27. Cell Mol Life Sci. 2018. PMID: 29080089 Free PMC article.
p53 Functions in Adipose Tissue Metabolism and Homeostasis.
Krstic J, Reinisch I, Schupp M, Schulz TJ, Prokesch A. Krstic J, et al. Among authors: prokesch a. Int J Mol Sci. 2018 Sep 4;19(9):2622. doi: 10.3390/ijms19092622. Int J Mol Sci. 2018. PMID: 30181511 Free PMC article. Review.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S, Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG. Huber K, et al. Among authors: prokesch a. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):337-348. doi: 10.1016/j.bbamcr.2018.08.017. Epub 2018 Aug 31. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30595160 Free PMC article.
51 results