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Is it time for chronopharmacology in NASH?
Marjot T, Ray DW, Tomlinson JW. Marjot T, et al. Among authors: tomlinson jw. J Hepatol. 2022 May;76(5):1215-1224. doi: 10.1016/j.jhep.2021.12.039. Epub 2022 Jan 20. J Hepatol. 2022. PMID: 35066087 Review.
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM. Draper N, et al. Among authors: tomlinson jw. Nat Genet. 2003 Aug;34(4):434-9. doi: 10.1038/ng1214. Nat Genet. 2003. PMID: 12858176
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM. Lavery GG, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. doi: 10.1210/jc.2008-0743. Epub 2008 Jul 15. J Clin Endocrinol Metab. 2008. PMID: 18628520 Free PMC article.
Glucocorticoids and non-alcoholic fatty liver disease.
Woods CP, Hazlehurst JM, Tomlinson JW. Woods CP, et al. Among authors: tomlinson jw. J Steroid Biochem Mol Biol. 2015 Nov;154:94-103. doi: 10.1016/j.jsbmb.2015.07.020. Epub 2015 Aug 1. J Steroid Biochem Mol Biol. 2015. PMID: 26241028 Review.
Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, Nasiri M, Yu J, Gough SC, Newsome PN, Tomlinson JW. Armstrong MJ, et al. Among authors: tomlinson jw. J Hepatol. 2016 Feb;64(2):399-408. doi: 10.1016/j.jhep.2015.08.038. Epub 2015 Sep 21. J Hepatol. 2016. PMID: 26394161 Free PMC article. Clinical Trial.
Non-alcoholic fatty liver disease and diabetes.
Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW. Hazlehurst JM, et al. Among authors: tomlinson jw. Metabolism. 2016 Aug;65(8):1096-108. doi: 10.1016/j.metabol.2016.01.001. Epub 2016 Jan 11. Metabolism. 2016. PMID: 26856933 Free PMC article. Review.
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD. Guida C, et al. EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11. EBioMedicine. 2019. PMID: 30639417 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
206 results